Acarbose

Chemical name

[1S-(1альфа,4альфа,5бета,6 альфа)]-0-4,6-Дидезокси-4- [[4,5,6-тригидрокси-3-(гид роксиметил)-2-циклогек сен-1-ил]амино]-альфа-D-��люкопиранозил-(1-4)-0-ал ьфа-D-глюкопиранозил-(1 -4)-D-глюкоза

Gross

C25-H43-N-O18

Characteristics

Oligosaharid obtained by fermentation of the microorganism Actinoplanes utahensis. It is a white, or almost white powder. Rat in the water. Molecular weight 645.6.

Indications

Caharnyi type 2 diabetes with poor diet (which rate shall not be less than six months), as well as the ineffectiveness of combination therapy derivative with sulfonylureas nizkokalorina diet.

Restrictions on the use of

The Fever, injuries, the operation and aftercare period, the application is only possible, if the expected benefits outweighs the potential risks. Children's age (safety and efficacy of the children are not identified).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, diabetic ketoacidosis, cirrhosis; Acute and chronic inflammatory bowel disease, cause digestive problems and intake; Gastrointestinal pathology high gazoobrazovaniem, Ulcerative Colitis, intestinal occlusion, incl. Partial or predisposition to it hernia large expressed violation of the kidney, pregnancy, breast-feeding.

Side-Effects

BAKER part of the intestine : jaundice, abdominalnaya pain, flatulence, Diarea.prochie : rarely spontaneous, tranzithornoe increase transaminaz (AST and ALT), a lower level gematokrita (without changes in the concentration of hemoglobin), a decrease in calcium, vitamin B_6 in plasma.

Patient interaction

The effect reduces activated carbon and other intestinal adsorbents, pharmaceuticals digestive enzymes containing pankreatin or amilazu. Tiazidnye dioretiki, corticosteroids, fenotiazina, hormones thyroid, estrogena, oral contraceptives, phenytoin, nikotinova acid simpatomimetiki, calcium antagonists, isoniazid and other means of giperglikemia significantly weaken specific activity (possible decompensation diabetes mellitus), derivatives, sulfonylureas increase.

Overdosing

Symptoms : increasing discomfort in the abdominal area, diarrhoea, Meteorizm.lechenie : none.

Precautions

Treatment should be under the control of blood glucose and / or urine testing glikozilirovannogo transaminaz and in the first year of treatment, one every three months, and further that periodically. The dose to 300 mg / day by further, but expressed little lower postprandialna io by an increased risk giperfermentemii (increased concentrations of AST and ALT in the blood). Together with the use of drugs sulfonylureas or insulin may develop gipoglikemii to adjust sugar in the food (glucose, but not sugar), or in / with the introduction dekstrozy or use glukagona (in the most severe cases).

Dosing and Administration

Inside, at the beginning of meals, and 25 mg three times a day. The dose to 100 mg three times a day passes through 4-8-nedle intervals and based on two criteria, the level of glucose in the blood after one hour after eating and personal hell. The normal dose for adults weighing 60 kg or less, 50 mg, weighing more than 60 kg to 100 mg three times a day.

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