Amaril

Roman name

Amaryl

The composition and the form of

1 tablet contains glimepirida 1, 2, 3 or 4 mg; in a contour acheikova packing 15 pcs. , in a cardboard bundle two packaging.

Pharmacokinetics

Has absolute biodostupnostthew, low-volume distribution (about 8.8 litres), a high degree of binding to plasma proteins (99%) and low-Cl (about 48 ml / min). Away has not had significant effects on the skin. C_max through 2.5 hours T_1/2 5-8 hours Place in the form of metabolizirovannom 58% of the urine, 35% from faeces. Violation of kidney function leads to an increase in Cl glimepirida and reduce its average concentrations in the blood (mitigated risk cumulation). The experiment found that glimepirida milk.

Indications

Insulinnezawisimy diabetes mellitus type II (when it is not possible to adequately control blood glucose with just diet and exercise, and reduce body mass index).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breast-feeding or move to insulin.

Contraindications

Гиперчувствительност ь (including from other sulfon- and sulfanilamidam) insulinzawisimy diabetes mellitus type I, diabetic ketoacidosis, diabetic precoma and coma, pregnancy, breast-feeding.

Patient interaction

Gipoglikemiceski effect reinforce other oral antidiabetics funds insulin, ACE inhibitors, allopurinol, anabolic steroids, the male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, dizopiramid, fenfluramin, feniramidol, fibrata, fluoxetin, guanetidin, izofosfamida, MAO inhibitors, miconazole, PASC, pentoksifillin (with Injecting a high dose), fenilbutazon, azapropazon, oxyphenbutazone, probenecid, hinolona, salicilata, sulfinpirazon, sulfanilamida, tetratziklin, tritokvalin, trifosfamida; weaken - acetazolamide, barbiturates, corticosteroids, diazoxid, dioretiki, adrenaline, etc. simpatomimeticalkie means glukagon, laxatives (after a long application), nikotinova acid (in high doses), and estrogena progesterona, fenotiazina, phenytoin, rifampicin, hormones thyroid gland. H_2-retseptorov blockers, clonidine, rezerpin, coumarin derivatives, alcohol may both raise or lower gipoglikemiceski effect.

Precautions

During treatment requires regular monitoring of glucose and glikozilirovannogo hemoglobin in the blood and glucose in the urine. Patients with serious liver and kidney can be shown at the insulin. In order to achieve an optimal effect a regular reception with diet, exercise. In the first few weeks can hypoglycaemia. Its development to lack of control doctor, malnutrition, changes in the diet, lack of food, the imbalance between the physical load and consumption of carbohydrates, alcohol, a breach of the liver and kidneys, overdose, uncompensated endocrine diseases affecting carbohydrate exchange. Caution must be exercised in the appointment of a бета-адреноблокаторо�� (lower tolerance to glukoze).

Dosing and Administration

The inside is not liquid, with enough liquid (about 0.5 minutes), the abundant breakfast. Initial dose (including transferring oral etc. противодиабетическог о drug), 1 mg once a day; if necessary daily intake gradually increased (1 mg every 1-2 weeks) to 6 mg. Elementary and supporting dose determined on the basis of regular monitoring of glucose in the blood and urine. With the improvement of diabetes increased sensitivity to insulino, which may require dose adjustment. Treatment is usually long.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

3 years

The registration

015530/01

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