Buformin

Chemical name

1-butilbiguanid (as hydrochloride or tosilata)

Gross

C6-H15-N5

Characteristics

The white crystalline powder bitter taste. Easily soluble in water and alcohol.

Of drugs

The drugs-gipoglikemicescoe. Is glucose uptake tissues, including muscle, delaying induction carbohydrates in the gut, stimulates anaerobnyy glikoliz, glukoneogenez injures in the liver. Increases tissue sensitivity to insulino reduces giperinsulinemia. Reduces appetite, reduces weight diabetics, obese. And fibrinoliticakimi properties. Gipoglikemicescoe the evolving 2-4 h, reaches its maximum after 4-5 hours and lasts for about 8 hours Quickly and almost completely absorbed from the digestive tract. Easily passes through gistogematicalkie barriers and penetrate various tissues. T_1/2, 3-7 p.m. Excreted mainly kidneys.

Indications

Diabetes mellitus type 2 in adults, including milder, инсулинрезистентност ь (in combination with insulin), primary and secondary resistance sulfonylureas; obesity.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, komatosnye state acidosis, albuminurija motivated diabetic nefropatii, ketonuria, defeated liver and kidneys, pancreatitis, severe cardiovascular and respiratory system disorders, infectious diseases, fever, gangrene limbs, chronic alcoholism, pregnancy, breast-feeding.

Side-Effects

For part of the intestine : loss of appetite, nausea, vomiting, a metallic taste, pain in epigastralna area ucaschenny Stul.prochie : weakness, decrease body weight, ketos with low alkalinity backup blood disorders, rarely allergic reaction (redness of skin, skin, skin itch).

Patient interaction

Enhance and prolong the effects of exogenous insulin. Gipoglikemiceski effect weaken fenotiazina derivatives (including aminazin), corticosteroids, tireotropona hormones, estrogena, mochegonne reinforce, MAO inhibitors, derivatives sulfonylureas, salicilata.

Overdosing

Symptoms : gipoglikemical Koma.lechenie : in the light cases, the immediate admission of pieces of sugar, sweet hot tea, fruit juice, corn syrup, honey; In the most severe cases, a 50% glucose solution (50 ml / and in the interior), in continuous / cefuroxim in 5-10% solution dekstrozy in / m glukagona a 1-2 mg, diazoxid inside of 200 mg every 4 h or 30 mg in / for a period of 30 minutes; oteke with brain-mannit and dexamethasone; monitoring the fast (every 15 min), the pH, urea nitrogen, creatinine, electrolytes.

Precautions

During treatment it is necessary to continually monitor the level of glycemia and renal function. Be wary designate at the time of therapeutic starvation and older patients. Admission drug out at least one week in advance of the operation.

Dosing and Administration

Inside, at the time of delivery. Insulinnezawisimy diabetes (type II) for the 100 mg morning and evening; Depending on the content of glucose in the blood and urine dose adjustments; The maximum dose of 300 mg / sut. Obesity is 100 mg / day in combination with anorexigennami drugs.

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