Carbutamide

Chemical name

4-Амино-N-[(бутиламино)к арбонил]бензолсульфо��амид

Gross

C11-H17-N3-O3-S

Characteristics

The white crystalline powder. Virtually nerastvorim in water, soluble in alcohol.

Of drugs

The drugs-gipoglikemicescoe. Does beta pancreas, increasing the number of endogenous insulin, facilitates the receptors in insulino органах-мишенях.Быстр о absorbed in the digestive tract. C_max achieved through 1hr Biotransformiroetsa in the liver. T_1/2, about 36 hours Excreted news in the form of metabolites, and unaltered.

Indications

Diabetes mellitus type 2.

Contraindications

Гиперчувствительност ь (incl. to sulfanil- etc. sulfonamidam), coma precoma, ketoacidosis, infectious diseases, the effects on the kidneys, pregnancy, breast-feeding (at the time of treatment must stop breastfeeding), Children and Youth age.

Side-Effects

Hypoglycaemia, diarrhoea phenomenon agranulozitos and lakopenia, porphyria, haemolytic anaemia, abnormalities in the liver and thyroid, allergic reactions.

Patient interaction

Sulfanilamida, salicilata, derivatives dikumarina, tetratziklin, levomicetin, MAO inhibitors, increase beta-adrenoblokatora effect tiazidnye dioretiki, glukokortikoida and difenin-weakened.

Precautions

Karbutamid appoint you must control peripheral blood. There is a need to periodically urine.

Dosing and Administration

Inside. Assign 1 hour before meals, starting with 1 g twice a day. Then (with effect) dose gradually reduced to 0.25 g twice a day. The maximum daily dose of 2 grams.

Directory → Metaboliki → Gipoglikemicakie synthetic and other means → Carbutamide