Chlorpropamide

Chemical name

4-Хлор-N-[(пропиламино)к арбонил]бензолсульфо��амид

Gross

C10-H13-Cl-N2-O3-S

Characteristics

The white crystalline powder without smell and taste. Nerastvorim in water, soluble in alcohol and chloroform. Molecular weight 276.74.

Of drugs

The drugs-gipoglikemicescoe. It stimulates the release of insulin from beta-kletok pancreas and increases the number of receptors in insulino organah-misheniah. And antidiureticescoy Aguostu.horosho drawn from the blood, the blood found in the first hours after admission. C_max is 2-4 hours T_1/2-36 p.m. Write memory (80-90% of dose) within 96 hours, including 20-30% unaltered. Gipoglikemiceski effect after a single admission goes on 24 hours

Indications

Diabetes mellitus type 2 diabetes nesharnyi.

Restrictions on the use of

Children's age (the effectiveness and safety of the children have not been established).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to sulfanil- etc. sulfonamidam), milder diabetes, ketoacidosis, coma, infectious diseases, disorders of the liver and kidneys, thyroid gland, lakopenia, granulozitopenia, pregnancy, breast-feeding.

Side-Effects

From the metabolic : very rarely hypoglycaemia, Giponatriemia.so part of the intestine : 1% urticaria, makulopapuleznaya Sapi.so the circulatory system and blood (blood, gemostaz) : lakopenia, agranulozitos, thrombocytopenia, pancitopenia, aplastic and haemolytic anaemia, eozinofilia.

Patient interaction

Gipoglikemiceski effect reinforce NPVS, salicilata, chloramphenicol, probenecid, indirect combined, sulfanilamida, beta-adrenoblokatora, MAO inhibitors. Tiazidnye dioretiki, corticosteroids, fenotiazina, estrogena, oral contraceptives, phenytoin, nikotinova acid simpatomimetiki, BAC, drugs tireoidnykh hormones, isoniazid-weakening effect. When coupled with the use of alcohol can disulfiramopodobnaya reaction.

Overdosing

Symptoms : Gipoglikemia.lechenie : at a moderate gipoglikemii-glucose ingestion downward adjustment of dose or diet. In severe (very rarely) in coma and convulsions, a 50% solution of glucose in / in cefuroxim and 10% glucose solution (to maintain blood glucose above 100 mg / m), a careful monitoring of blood glucose within 24 to 48 hours

Precautions

Patients coming in the treatment of insulin for treatment hlorpropamidom should be under strict medical control. Be wary appoint people who suffered liver disease.

Dosing and Administration

Inside (within 30 minutes before eating), the initial dose of 0.25 g once a day (morning), a dose increase to 0.5 g, in the first week or up to 0.75 grams in the second. In the case of the normalization of glycemia dose gradually reduced to a supporting-0,125-0,25 g / sut. Older patients appointed dose 0,1-0,125 g / sut. In nesharnom diabetes initial dose of 57 g / day (if necessary, to 0.25 g / day).

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