Diabeton mb

Roman name

Diabeton # MR

The composition and the form of

1 tablet contains gliklazida 30 mg; blistere in 30 pcs. , in box 1 or 2 blisters.

Of drugs

Gipoglikemicescoe. It stimulates the secretion of insulin beta-kletkami islets Langergansa has expressed экстрапанкреатически м effect. Metabolic characteristics complemented gemovskulyarian action. In diabetes type 2 restores first peak secreting insulin in response to blood flow and makes the second phase of secreting insulin. A significant increase in insulin secreting there, in response to the stimulation resulting from the admission of food and the introduction of glucose. Increases sensitivity peripheral tissues to insulino by promoting action of insulin on muscle glikiencintetazu reduces education glucose in the liver, normalize levels of prandial glucose. Decreases risk trombozov small receptacles of lipid peroxides in plasma increases the activity eritrocitarna superoxidedismutase.

Pharmacokinetics

Completely absorbed, the plasma progressively increased, reaching a peak at 12 h after administration. Away does not affect the skin. The relationship between the dose and the concentration curve drug plasma is a linear dependence on time. Linking blood plasma approximately 95%. Predominantly metabolized in the liver, and presented mainly with urine : in the urine revealed less than 1% of native products. The production of active metabolites in plasma were observed. T_1/2 is about 16 hours The elderly do not have any significant clinical changes farmakokineticeskih parameters.

Farmakodinamika

Single dose of 30 mg effectively gliklazida concentration in plasma over 24 hours

Indications

Insulinnezawisimy diabetes (type II), combined with diet, in cases where only the diet is not enough to control the level of blood glucose.

Contraindications

Гиперчувствительност ь (incl. other sulfonamidam) insulinzawisimy diabetes (especially teenagers), diabetic ketoacidosis, diabeticescoe prekomatosnoe state severe kidney or liver failure, pregnancy (recommended at the insulin), breast-feeding.

Side-Effects

Hypoglycaemia, gastrointestinal disorders, including nausea, neuralgia, diarrhoea or constipation (these symptoms can be avoided or reduced them to a minimum, if the product at the luncheon); rarely irritated skin and mucous membranes : itching, urticaria, piatnistopapuleznaya rashes; hematologic violations : anaemia, lakopenia, B19; increased liver enzymes (AST, ALT, alkaline phosphatase), yellows (very rarely). If you have symptoms of jaundice holetsaticescoy to interrupt treatment.

Patient interaction

Miconazole, flukonazol, fenilbutazon, beta-adrenoblokatora, ACE inhibitors, alcohol increases the risk of gipoglikemii; Danazol, chlorpromazine, glukokortikoida, tetrakozaktid, progestagena, ritodrin, salbutamol, terbutalin (in / in the introduction) Raising the level of blood glucose.

Precautions

With the utmost care appoint patients older people who do not have a balanced diet, weakened patients, as well as suffering napochechnikova or lectures Nedostaternstew.vo treatment should be regular monitoring of blood glucose and glucose content in the urine; Have regular balanced (especially carbohydrates) food, necessarily includes breakfast.

Dosing and Administration

Inside, adults, at the luncheon to pick dose individually. The initial recommended dose (including for the elderly over 65 years of age), 30 mg, each following change may doses at intervals of not less than 2 weeks; Daily dose-120 mg per reception. The passage rate for the next day, it must be Uveliciti.mozhno be combined with biguanidami, besides alfa-glikozidaza or insulin.

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