Diabrezid

Roman name

Diabrezide #

The composition and the form of

1 tablet contains gliklazida 80 mg; in the box two blisters on 20 pcs.

Of drugs

Gipoglikemicescoe. Increases tissue sensitivity to insulino and stimulates insulin secretion of pancreatic cancers, increases glikiencintetaza activity.

Pharmacokinetics

Well drawn, bioavailability of 80%. After receiving a single dose of 80 mg C_max (3-8 µ g / ml) is a 2-4 (8) hours, 24 hours reduced to the level of 2 µ g / J At 85-99% associated plasma protein (volume distribution-24 litres). T_1/2-12 p (women and older longer than men). Intensive metabolised in the liver (oxidation, glukuronizatia) to 7 inactive metabolites; 60-80% (mostly in the form of metabolites) in the 96 hours to return with urine.

Farmakodinamika

It gipoglikemia increases tolerance to glukoze reduces raising sugar in the blood after eating, agregatia inhibits adhesion and platelets, activates fibrinoliz improves microcirculation.

Clinical pharmacology

The effect reaches through 4-5 hours The excessive gipoglikemii unlikely. Impact of beta-tromboglobulina and optimizes ratio tromboksan A_2 / 6-keto-prostaglandin-f_1, stimulates synthesis prostatziklina. While affect the ratio of plasma lipids and lipoprotein, reduces the likelihood and the speed of development of micro and macrososudistah complications of diabetes.

Indications

Insulinnezawisimy diabetes (type II).

Pregnancy and lactation

Not recommended.

Contraindications

Гиперчувствительност ь (including from other derivative sulfonylureas, sulfanilamidam, tiazidam); severe burns, trauma, infection; ketoacidosis, acute or chronic renal failure, liver disease, insulinzawisimy diabetes, fever, prolonged nausea and vomiting.

Side-Effects

Hypoglycaemia, dizziness, nausea, vomiting, stomachache, diarrhea; Heart, giponatriemia, increasing transaminaz liver, skin rashes, itching of the skin.

Patient interaction

Effects, including side (tides of blood to the face and head, oppression CNS, convulsions, nausea) increased alcohol zimetidin weakening - acetazolamide and metazolamid.

Overdosing

Symptoms gipoglikemii-cold sweat, tremor, cold or pale skin, tachycardia, a sense of hunger, anxiety, impaired consciousness, dizziness, etc. In the case of a moderate gipoglikemii recommended reducing dosage.

Precautions

To increase the effectiveness of the treatment, it was important to adhere strictly to diet. Showing regular measurement of glucose : the recommended compensation prandial glycaemia (80-120 mg / m), at night (100-140 mg / m) and the level of glikozilirovannogo hemoglobin (less than 7%).

Dosing and Administration

Inside, at the time of delivery, in a daily dose of 80-mg daily, at the luncheon, and then dose gradually increased to 40-80 mg per week to normalize blood glucose. Average daily intake - 160-200 mg, the maximum 320 mg in 1 or 2 admission. Patients with liver disease are encouraged to lower doses.

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