Glibenez retard

Roman name

Glibenese retard

The composition and the form of

1 tablet covered osmoticescoy liner contains glipizida 5 or 10 mg; Patients in the high density polyethylene 30 pcs. , in the box one bottle.

Characteristics

Oral gipoglikemisiruty product of a group of derivative sulfonylureas, is a special form of resistance with a slow release glipizida.

Of drugs

Gipoglikemicescoe. It stimulates the release of insulin функциональноактивны х beta-kletok pancreas. Lowers Hba_1s level and the concentration of glucose in the blood prandial. Do insulinotropony response to a meal (the increased insulin and S-peptida maintained for a period of six months after therapy).

Indications

Insulinnezawisimy diabetes (type II) in patients with normal or abnormal weight (with inefficiency adequate diet).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь glipisidou to; insulinzawisimy diabetes, especially uvenilny, diabetes accompanied by ketoacidosis or prekoma; severe kidney or liver failure; pregnancy, breast-feeding.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : lakopenia, agranulozitos, thrombocytopenia, haemolytic or aplastic anaemia, Pancitopenia.so part of the intestine : nausea, diarrhea, discomfort in epigastralna area. As with the use of other drugs sulfonilmocevinnah may develop holetsaticescoy jaundice, toxic hepatitis (to withdraw treatment). Sometimes there is a slight or moderate increase in GOT, LDG, alkaline phosphatase, residual nitrogen urea and creatinine (link these changes with the hosting glipizida unknown). From the metabolic : hypoglycaemia. Using drugs sulfonilmocevinnah describe liver porfirii and antabushnykh reactions; Giponatriemii.so cases of skin : itching, urticaria, makulopapuleznaya rashes.

Patient interaction

Miconazole, fenilbutazon, ethanol, beta-adrenoblokatora, flukonazol, ACE inhibitors (captopril and enalapril), salicilata raise gipoglikemisiruty effect. Danazol, chlorpromazine (100 mg / day or more), glukokortikoida, tetrakozaktid, progestagena (in high doses), weakened gipoglikemisiruty effect.

Precautions

In patients at risk (in the face of the liver, kidneys, the weakened and depleted patients, patients receiving regular food, in old age) initial and supporting dose should be low to avoid gipoglikemicakih reactions. When transferring patients from receiving other derivative sulfonylureas on Glibenez retard needed careful monitoring blood glucose within 2 weeks. If you have expressed gipoglikemii be adequate therapy and glucose monitoring of patients within 48 hours The safety and effectiveness of drugs in children have not been established.

Dosing and Administration

Inside pills With the entirely non razjevarve not divided into parts or razlamarve. Dose selected individually. The recommended initial dose of 5 mg / day one (at the luncheon), it may increase the dose of 5 mg every few days (required monitoring concentrations of glucose in the blood). Equilibrium concentration glipizida plasma is the fifth day of treatment (for people over 65 years to reach equilibrium concentrations likely to be involved in 1-2 days больше).Поддерживающа я Therapy : effective control blood glucose is the result of the drug once / sut. The maximum recommended dose of 20 mg (with a maximum reduction in blood glucose). Patients receiving быстровысвобождающий ся glipizid the dose of 5 mg to 20 mg per day, can be translated to the reception Glibeneza retard once per day at the nearest equivalent to the total daily intake. For patients receiving other gipoglikemisirute drugs, a transition period in translation into Glibenez retard is not required.

Storage conditions

tabl.s controlir.vswob. : List B. In dry the dark place at a temperature of no higher than 30 ° C

Shelf life

tabl.s controlir.vswob. : 2 grams.

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