Glibenez

Roman name

Glibenese

The composition and the form of

1 tablet contains glipizida 5 mg; blistere in 10 pcs. , in a cardboard box three blisters.

Of drugs

Gipoglikemicescoe. Increases insulin secretion beta-kletkami ostrovkova tissue pancreas in response to eating, increases tissue sensitivity to insulino (increasing the number of receptors).

Pharmacokinetics

Absorbed in the digestive tract quickly and fully. Food does not affect the full intake and distribution, but delaying removal of about 40 minutes. After one reception (5 mg) concentration in plasma peaking at 1-3 The bonding with the plasma protein is 98-99%. T_1/2 with in / and in a dose-2-4 pm Biotransformiroetsa predominantly in the liver. The metabolites (inactive gidrauxilirovania products and polar compared) derived mainly from urine. In unaltered in the urine found less than 10% imposed doses.

Farmakodinamika

Alleviate or diminishes glukozuriu, reduces symptoms of diabetes : poliuriu, polidipshiyu, itchy skin; Lipoproteidnyi improves plasma profile. Gipoglikemiceski effects after taking one dose lasts 24 hours

Indications

Insulinnezawisimy (type II) diabetes mellitus (in addition to the diet).

Contraindications

Hypersensitivity, insulinzawisimy (uvenilny) diabetes, diabetic ketoacidosis with coma or without it.

Side-Effects

Hypoglycaemia, nausea, pain in the area epigastralna, diarrhea / constipation, headache, dizziness, drowsiness, and a moderate increase in the ACT, LDG, alkaline phosphatase, residual nitrogen urea and creatinine, jaundice (described one case), allergic skin reactions (erythema, and korepodobne makulopapuliarnae skin, urticaria, itching, eczema, etc.).

Patient interaction

Gipoglikemiceski effect - increased NPVS, sulfanilamida, chloramphenicol, probenecid, cumarins, MAO inhibitors, beta-adrenoblokatora (out of the food), reduced-dioretiki (incl. tiazidnye), corticosteroids, fenotiazina, hormones thyroid, estrogena, oral contraceptives, phenytoin, nikotinova acid simpatomimetiki, calcium antagonists, isoniazid.

Precautions

Be wary appoint elderly, the weak and depleted patients with severe liver disease or kidney napochechnikova and Pensions failure. At the time of treatment, there is a need to control the content of glucose in the blood and urine, incl. to identify possible primary or secondary resistance, lactoirute women should stop breast-feeding. Using Glibeneza during pregnancy, it is necessary to lift a month before expected delivery. It should be borne in mind that the safety and effectiveness in children have not been studied.

Dosing and Administration

Inside, one for 30 minutes before eating. Initial dose, 5 mg (with minor diabetes in old age and Hepatic 2.5 mg) to breakfast or lunch. In the future (if necessary) dose increased to 2.5-5 mg every few days. Doses of more than 15 mg / day are several receptions. The maximum daily dose of 40 mg.

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