Glibenclamide awd 5

Roman name

Glibenclamid AWD 5

The composition and the form of

1 tablet contains glibenklamida 5 mg; in vials of 120 pcs. , in the box one bottle.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract. C_max after a single reception achieved in 1-2 hours Linking plasma protein-99%. T_1/2 - 4-11 hours The liver completely biotransformiroetsa 2 inactive metabolita, one excreted with the urine, and the second appears to jelchew through blood.

Indications

Insulinnezawisimy diabetes (type II) in adults (in the case of poor nutrition, lower body mass index and physical activity).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, uvenilny insulinzawisimy diabetes mellitus (type I), insulinnezawisimy diabetes (type II) labile currents ketoacidosis, precoma, diabetic coma, kidney and liver failure, pregnancy, breast-feeding.

Side-Effects

Hypoglycaemia, diarrhoea phenomenon liver dysfunction, holetsatical jaundice, tranzitorne pareza breach of blood, allergic reactions.

Patient interaction

Increases gipoglikemiceski effect beta-adrenoblokatora, 25.06.1997 means allopurinol, zimetidin, klofibrat, cyclophosphamide, isobarin, MAO inhibitors, sulfanilamida long action salicilata, chloramphenicol, tetracycline, alcohol; Weaken, barbiturates fenotiazina, incl. chlorpromazine, phenytoin, diazoxid, acetazolamide, simpatomimetiki, indometacin, nikotinata, glukagon, glukokortikoida, hormones thyroid, estrogena, oral contraceptives, saluretiki, salt lithium, laxatives (in high doses), alcohol.

Precautions

The caution used in the elderly, the handicapped patients with the defective function of the liver and kidney. There is a need to continuously monitor the level of glucose in the blood serum (at least once in three months). At the time of treatment required Not taking alcohol. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. It should be borne in mind that the clinical manifestations gipoglikemii may be masked in the admission beta-blokatorov, clonidine, rezerpina, guanetidina.

Dosing and Administration

Inside, a small amount of liquid for 30 to 60 minutes before eating. Dosing set individually. Typically, the initial dose of 2.5 mg morning; If necessary dose increase of 2.5 mg per week to normalize blood glucose. When replacing other protivodiabeticakih for glibenclamide - 2.5-5 mg morning dose supporting-5-10 mg / sut. The maximum daily dose is 15 mg (in exceptional cases, 20 mg).

Storage conditions

List B. Under normal circumstances,

Shelf life

5 years

The registration

003292

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