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Glibomet

See also Repowide

Roman name

Glibomet

Characteristics

Combined gipoglikemiceski product.

Pharmacokinetics

The farmakokinetike Glibomet drug is not available.

Indications

Insulinnezawisimy diabetes mellitus (type 2) in the case of poor diet alone or oral gipoglikemicakimi drugs.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity to components of the preparation. Latent form of diabetes mellitus (diabetes, characterized by the absence of clinical symptoms of the disease). Insulinozawisimaya form of diabetes. Ketoacidosis (acidification due to the excessive content in the blood ketonovykh phone). Diabetic (associated with increased blood sugar) prekoma (partial loss of consciousness, the initial stage of coma characterized by continuing pain and Reflective reactions), coma (complete loss of consciousness, characterized by the complete absence of responses of the external stressors). The level of serum creatinine (indicator of the level of nitrogen), exceeding 12 mg / O Determination of the liver or kidney. Period injection urografii (рентгеноконтрастног�� study kidney and mochevyvodyashih ways). Heavy cardiovascular disease (heart failure, cardiogenny shock of peripheral circulation). Violations of breath. Under napochechnikov crust. Chronic alcoholism. Starvation. Underweight. Bleeding. Shock. Gangrene (eliminate tissues, in which they either mummified / allergy / or in gnilostnomu break). Pregnancy.

Specific guidance

The treatment is carried out only under the supervision of the admission Vraca.pri drug should observe diet and the level of self-blood glucose levels.

Patient interaction

Gipoglikemiceski effect increases dikumarol (including its derivatives), beta-adrenoblokatora, zimetidin, auxitetratziklin, allopurinol, MAO inhibitors, sulfonamida, fenilbutazon (including its derivatives), chloramphenicol, probenecid, salicilata, miconazole (pill form), sulfinpirazon, alcohol (in large quantities); Weaken - adrenaline, corticosteroids, oral contraceptives, hormones thyroid, tiazidozodergaszczye diureticeskie means barbiturates. Perhaps of greater economies of protivosvertavath средств.Одновременны�� reception zimetidine can increase the risk of molernkislogo azidoza.

Overdosing

The drug overdose Glibomet yet to materialize.

Storage conditions

List B. In a dry, the dark spot.

Shelf life

3 years

The registration

012183/01-2000

The drug forms

White, round, 4.2.2 pills Film-coated with Kołki for fission.

Of drugs

Combined oral (adopted by mouth) gipoglikemiceski (reduction blood sugar) product. The combination of two active substances makes it possible to reduce the dose of each substance. Glibenclamide is derived sulfonylureas II generation. And pankreaticski (affects the pancreas) and vnepankreaticski effects. On the one hand, increases the secretion (a) insulin by lowering the threshold of annoyance betacletok solution (cells expressing insulin) pancreas, on the other hand, increases the sensitivity to insulino and degree of bonding with kletkami-misheniami. Moreover, the medication has gipolipidemicescoe (decreasing the lipid / fat / blood), and to reduce the likelihood tromboobrazovania (education bunch blood krovenosnom cup). Meg-morfin belongs to the group biguanidov, acting clear enough. It increases glucose disposal muscles, slowing glkjoneogenez (education glucose) in the liver, slows absorption (skin) carbohydrates in the gut.

Indications for use

Insulinonezawisimaya form of diabetes; Inefficiency diet, or a combination of diet and derivatives sulfonylureas; Primary or secondary resistance (resistance) to drugs sulfonylureas; Reducing sensitivity to sulfonylureas drugs as a result of their continuous use.

Dosing and Administration

Dose of drug and duration of treatment are individually. The recommended initial dose is two tablets a day at meal times. The maximum daily dose of the drug should not exceed 2 grams per vial. If necessary dose of the drug should be gradually reduced to the minimum controlling blood sugar levels.

Side-Effects

Perhaps the gipoglikemii (lowering of blood sugar below average) from astenizirovannah (weakened) of the patients, patients senile age, physical load, frequent meals, drinking alcohol, as well as in violation of the express liver and / or kidney. In addition, there may be headache, pain in epigastralna area (the abdomen, located directly beneath mud arches rib and the sternum), diarrhoeal disorders (loss of appetite, nausea, vomiting, diarrhea), and allergic reactions (skin rash). In some cases, in patients with renal failure after taking alcohol may lactatsidoza development (dollars due to increased levels of lactic acid). Described increases in the serum levels of lactic acid; Azotemii (high content in the blood products containing protein exchange); Lower blood pH (acidity blood). It is rare convertible changes gemopoaiza (blood).

Form of

Pills containing 2.5 glibenklamida mg and 400 mg metformina hydrochloride Film-coated, in a package of 40 pieces.

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