Gliquidone

Chemical name

N-[(Циклогексиламино)к��рбонил]-4-[2-(3,4-дигидро- 7-метокси-4,4-диметил- 1,3-диоксо-2(1H)-изохинол��нил)этил]бензолсульф��намид

Gross

C27-H33-N3-O6-S

Characteristics

The white crystalline powder. Nerastvorim in water, poor in spirit.

Of drugs

The drugs-gipoglikemicescoe. It stimulates the beta pancreatic islets to the mobilization and release insulin, lowers glukagona level in the blood, increases the number of receptors in insulino tkaniah-misheniah. Gipoglikemicescoe effect is manifested through 60-90 minutes, reaches its maximum after 2-3 hours and lasts eight C.bystro and almost completely absorbed from the digestive tract. C_max achieved in 2-3 hours Metabolised in the liver. T_1/2-1.5 hours Write mainly gastrointestinal (with jelchew and faeces), and a small number (5%), kidney.

Indications

Diabetes mellitus type 2 in patients with middle-aged and elderly people with no compensation only fast diet.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to sulfanil- etc. sulfonamidam); prekomatosnoe and comatose condition; diabetes, oslojnenny azidozom and ketoacidosis; diabetes mellitus type 1; pregnancy and breast-feeding.

Side-Effects

From the metabolic : rarely Gipoglikemia.so part of the intestine : seldom is a loss of appetite, nausea, vomiting, Dispepcia.prochie : rarely headache, allergic skin reaction (dermatitis), itching, lakopenia, B19.

Specific guidance

Upon treatment with oral etc. противодиабетическим и drugs similar action at its glikvidon dose depended on the degree of exchange.

Patient interaction

Effect increase butadion, chloramphenicol, tetratziklin, coumarin derivatives, cyclophosphamide, sulfanilamida, MAO inhibitors, tiazidnye dioretiki, beta-adrenoblokatora, salicilata, alcohol weakening - oral contraceptives, chlorpromazine, simpatomimetiki, hormones, hormones the thyroid gland, preparations containing nicotine acid. Compatible with biguanidami.

Overdosing

Symptoms : Gipoglikemia.lechenie : ingesting sugar (glucose better), as appropriate, in / in or / drip in a glucose solution.

Precautions

During treatment required monitoring of glucose in the blood and urine, the diet. Passes mealtimes or excess doses may lead to a commitment gipoglikemicescomu effect. The surgical interventions, infections involving high body temperature, there may be a need for a temporary transfer of the patient to insulin. In severe renal failure needs constant medical supervision. It should be borne in mind the possibility of lower tolerance to alcohol.

Dosing and Administration

Inside, the food, in the initial dose of 15 mg once (morning); Then gradually increase the dose (up to 120 mg / day) and the multiplicity of admission (where appropriate to 3 times).

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