Glukotrol hl

Roman name

Glucotrol XL

The composition and the form of

1 tablet covered osmoticescoy liner contains glipizida 5 or 10 mg; in plastic bottles to 30 pcs.

Of drugs

Gipoglikemicescoe. It stimulates the secretion of insulin beta-kletkami ostrovkovogo apparatus pancreas.

Pharmacokinetics

Absorbed adequately. After 2-3 h after administration of a plasma in significant concentration, which is gradually increasing, reaching a peak six hours Admission every day maintains effective for 24 hours Bioavailability to 90%. In the blood of 99% is associated with malnutrition. Stable concentration in plasma achieved 5 day use (in patients over 65 years - to two days later). Pharmacokinetics glipizida linear in the range of doses of 60 mg. Eliminated by biotransformation in the liver, only less than 10% imposed dose excreted unchanged to the urine and faeces; Biotransformation products also derived from the urine (80%) and faeces (10%).

Farmakodinamika

Impact on the level of glucose in the blood by stimulating the release of insulin pancreatic cancers; Insulinotropony increases effect food in patients with diabetes.

Indications

Insulinnezawisimy diabetes mellitus (with abnormal or normal weight).

Pregnancy and lactation

Contraindicated in pregnancy. It should be carefully appoint lactating women (hypoglycaemia possible in newborns).

Contraindications

Hypersensitivity, insulinzawisimy diabetes (uvenilny diabetes, diabetes, accompanied by ketoacidosis or prekoma); Severe kidney or liver failure; Stenoses digestive tract; Child.

Side-Effects

Hypoglycaemia; Nausea, diarrhea, discomfort in epigastralna area; Holetsatical jaundice, chronic hepatitis; Lakopenia, agranulozitos, thrombocytopenia, haemolytic or aplastic anaemia, pancitopenia, itching, urticaria, makulopapuleznaya rashes.

Patient interaction

Effect of increase-miconazole, fenilbutazon, alcohol, beta-adrenoblokatora, ACE inhibitors (captopril, enalapril), acetylsalicylic acid (in high doses), sulfanilamida reduce-danazol, chlorpromazine (100 mg / day), and glukokorticosteroida tetrakozaktid (also for the local application), progestagena, ritodrin, salbutamol, terbutalin (dropped).

Precautions

Not recommended for use in combination with mikonazolom. During treatment, it is necessary to avoid alcohol.

Dosing and Administration

Inside pills With the whole (not liquid and razlamawer apart). Initial dose of 5 mg / day at the luncheon to raise the dose at intervals of a few days, as up to 20 mg per day.

Storage conditions

tabl.p.o. : List B. In safe dry place so that the temperature does not exceed 30 ° C

Shelf life

tabl.p.o. : 3 and

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