Манинил 1.75

Roman name

Maninil # 1.75

The composition and the form of

1 tablet contains glibenklamida mikronizirovannogo 1.75 or 3.5 mg or glibenklamida 5 mg; in vials of 120 pcs. , in the box one bottle.

Characteristics

Микронизированный Манинил-tech измельченная specifically form глибенкламида allowing optimal фармакокинетический and фармакодинамический profile.

Of drugs

Gipoglikemicescoe. And pankreaticski and экстрапанкреатически м effects. Pankreatical activity evident in the stimulation of insulin beta-kletkami pancreas, экстрапанкреатическа я - increased sensitivity инсулиновых receptors and тканей-мишеней (through stimulation тирозинкиназы) to инсулину, repression and глюконеогенеза гликогенолиза in печени.Уменьшает risk of complications инсулиннезависимого diabetes mellitus (vascular, retinopathy, нефропатии, cardiopathies), and mortality associated with diabetes диабетом.Оказывает кардиопротективное and антиаритмическое action reduces агрегацию platelets.

Pharmacokinetics

Quickly and completely absorbed in the digestive tract. Linking plasma protein-95%. T_1/2 10 h. The liver biotransformiroetsa education inactive metabolites. Report the news (50%) and liver (50%). Cumulation Otsutstvet.skorosti intake mikronizirovannogo Maninila above (can be taken directly to the food), bioavailability 100%.

Clinical pharmacology

Through a combination of early C_max микронизированного Манинила, his гипогликемический effect virtually peak постпрандиальной io, which makes the soft exploration, reduced risk гипогликемии (T_1/2 shorter), and daily need for глибенкламиде may be decreased by 30%.

Indications

Insulinnezawisimy diabetes mellitus (type 2).

Contraindications

Гиперчувствительност ь.

Side-Effects

Diarrhoeal disorders, it is rarely giperergicakie reaction (rash, the fever, pain in joints, proteinurija).

Patient interaction

Effect increase ACE inhibitors, 25.06.1997, beta-adrenoblokatora, biguanida, zimetidin, coumarin derivatives, fluoxetin, MAO inhibitors, miconazole, PASC, pentoksifillin, fosfamida, rezerpin, salicilata, sulfonamida, tetratziklin; Weaken - acetazolamide, barbiturates, chlorpromazine, diazoxid, glukokortikoida, glukagon, gestagena, estrogena, nikotinata, saluretiki, hormones thyroid, simpatomimeticalkie funds. Alcohol can both enhance, and maintain (with chronic alcoholism) gipoglikemicescuu activity.

Overdosing

Symptoms : Gipoglikemia.lechenie : sugar inside or easily uswoyaemye carbohydrates (in the lungs cases), in / in 40-80 ml of 40% glucose solution, and then / in infuzionno 5-10% glucose solution (in the most severe cases); In / m or m / to 1-2 mg glukagona.

Precautions

It should be borne in mind that, against the background of beta-adrenoblokatorov, clonidine, and guanetidina rezerpina week gipoglikemii symptoms may not occur, making it difficult to timely diagnosis overdoses. Be wary appoint patients with severe interkurrentnami diseases, and surgery, injuries (possible transfer patient to be treated with insulin), drivers of vehicles and people skills relate to the high concentration of attention, or those engaged in potentially hazardous activities.

Dosing and Administration

Inside, in the morning and evening before food. Dose set individually depending on the severity of the disease. Initial dose-1 / 2 table. , The average two-table. a day with a maximum 3-4 table. Sutki.tri in dosage forms for the 20 potential dosing schemes.

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