Metfogamma 500

Roman name

Metfogamma # 500

The composition and the form of

1 tablet coated liner contains metformina hydrochloride 500 or 850 mg; blistere in 10 pcs. , in box 3, or 12 blisters.

Of drugs

Gipoglikemicescoe. Glukoneogenez stops in the liver and reduces the absorption of glucose from the intestines, increasing peripheral glucose utilization, increases tissue sensitivity to insulino. Impact of triglycerides and low-density population in the blood. Provides fibrinoliticescoe Effects (stupid action activator inhibitor plazminoguena woven type), stabilizes or reduces weight.

Pharmacokinetics

Bioavailability after intake of a standard dose of 50-60% C_max in plasma achieved in 2 hours Virtually no longer associated with a plasma protein appears unchanged to the kidneys. T_1/2 is 1.5-4.5 hours

Indications

Diabetes mellitus type 2 (insulinnezawisimy) without propensity to ketoatsidozu (especially in patients suffering from obesity).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, diabetic ketoacidosis, diabetic precoma and coma expressed violations of the kidneys and liver, cardiac and respiratory distress, the acute phase of myocardial infarction, acute violation of cerebral circulation, dehydration, state, which may contribute to the development of molernkislogo azidoza, incl. chronic alcoholism; molernkisly acidosis and guidance to him in the history, pregnancy and breast-feeding.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : in some cases megaloblastnaya Anemia.so part of the intestine : nausea, vomiting, pain in the abdomen, diarrhoea, loss of appetite, metallic taste in the Rtu.so metabolism : hypoglycaemia, in rare cases, molernkisly acidosis (to be a лечения).Аллергически е reactions : skin rash.

Specific guidance

Is not recommended for treatment of acute infectious diseases or chronic Friends инфекционно-воспалит��льных diseases, trauma, acute surgical diseases before surgery, and within two days after the elections, as well as during the two days before and after the implementation of diagnostic studies (X-ray radiation and the use of contrast media). It should not be used in patients with diet comply with the restriction of calories (less than 1000 kcal / day). We do not recommend the use of the drug in people over 60 years of age who perform strenuous physical work (as a result of increased risk of molernkislogo azidoza).

Patient interaction

Derivative sulfonylureas, acarboza, insulin, NPVS, MAO inhibitors, auxitetratziklin, ACE inhibitors, derivatives klofibrata, cyclophosphamide, beta-adrenoblokatora increase gipoglikemicescoe effect. Effect weaken glukokorticosteroida, oral contraceptives, adrenaline, etc. simpatomimetiki, hormones thyroid, tiazidnye and petleve "dioretiki, derivatives fenotiazina, nicotinic acid. Zimetidin slows down metformina, and increases the risk of development of molernkislogo azidoza. Ml relaxed kumarinovykh anticoagulants. The combination of derivatives sulfonylureas and insulin (requires careful monitoring blood glucose).

Overdosing

Symptoms : molernkisly Azidoz.lechenie : Hepatology, symptomatic therapy.

Precautions

It continuously monitor kidney function, the level of glucose in the blood. At least twice a year, as well as when there mialgii should determine the content of lactate in the plasma.

Dosing and Administration

Inside, at the time of delivery, are proglatawaya and squeezed enough fluids (a glass of water). Dose is individually depending on the level of glucose in the blood. Initial dose-table 1-2. Metfogamma 500 or one table. Metfogamma 850 per day (equivalent to 500 mg or 850 mg metformina hydrochloride), the future may gradual increase in dose, depending on the effect. Maintaining daily intake Table 2-4. Metfogamma 500 (2,000 mg) or Table 1-2. Metfogamma 850 (850-1700 mg). Maximum daily intake Table 6. Metfogamma 500 (3000 mg) or 2 table. Metfogamma 850 (1700 mg). Patients who are older recommended daily dose should not exceed 850 mg. Daily dose recommended to accept 2 admission (morning and evening). The course of treatment time.

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