Metformin-bms

Roman name

Metformin-BMS

The composition and the form of

1 tablet coated liner contains metformina hydrochloride 500 or 850 mg; in the plastic containers of 100 or 500 pc.

Of drugs

Gipoglikemicescoe. Do glucose disposal muscles, delaying induction carbohydrates in the gut, glukoneogenez down in the liver, increases the sensitivity of tissues to insulino.

Pharmacokinetics

Bioavailability is 50-60%. Absorption occurs relatively slowly compared to the rapid ascent. Return via the kidneys, mostly in unmodified form; Sometimes kidney exceed Cl Cl creatinine and dependent on it.

Farmakodinamika

Decreases the concentration of glucose in the blood, in the presence of endogenous or exogenous insulin. Could reduce weight in patients with diabetes.

Indications

Diabetes mellitus type II (stable, not aggravated ketoacidosis, in adulthood, particularly in patients with overweight).

Pregnancy and lactation

During pregnancy is not recommended; On the application during lactation, no data is available.

Contraindications

Ketoacidosis, diabetic coma; Severe kidney, liver or female heart failure; Recently moved myocardial infarction.

Side-Effects

Metal taste in the mouth, nausea, anorexia, diarrhoea; Increasing the concentration of vitamin B_12 (to within a few years); Molernkisly acidosis (in old age, with limited kidney function); Allergic reactions.

Overdosing

Possible in the case of a combination of derivatives sulfonylureas, insulin or alcohol. Symptoms : nausea, diarrhoea, abdominal pain, shortness of breath and other manifestations molernkislogo azidoza. Treatment : intensive therapy aimed primarily at reducing the loss of fluids and correction metabolism.

Precautions

The special monitor patients with human kidney function (Metformin excreted kidneys).

Dosing and Administration

Inside, at the time of delivery. Dose set individually. The recommended initial dose-500 mg twice a day; This dose can be gradually increase to the maximum : 1 g three times a day; Normal average dose of 1.7 grams per day, one in the morning (at the luncheon) or twice a day (the poldozy) in the morning and evening.

Storage conditions

tabl.p.o. : List B. In a dry place so that the temperature does not exceed 30 ° C

Shelf life

tabl.p.o. : 5 years

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