Novonorm

Roman name

NovoNorm #

The composition and the form of

1 tablet contains repaglinida 0.5, 1 or 2 mg; blistere in 15 pcs. , in box 2 blisters.

Of drugs

Gipoglikemicescoe. Interacts with receptors on membranes beta-kletok pancreas and helps close Atf-zawisimah channels is depoliarizatia membranes and the opening of calcium channels. Increased flow of calcium induces secretion of insulin beta-kletkami and released into the blood system.

Pharmacokinetics

Well drawn from the blood. Away does not affect the removals and the speed of impact. C_max achieved through one hour after administration. Located plasma for 4-6 hours T_1/2-1 p.m. Absolute bioavailability of 63%. The distribution-30 litres. Linking blood plasma proteins is about 98%. Metabolised in the liver, is excreted in jelchew, about 8% from urine, less than 1% from faeces.

Indications

Insulinnezawisimy diabetes mellitus (type 2).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, insulinzawisimy diabetes mellitus (type 1), a negative sample for c-peptid, diabetic ketoacidosis, severe functional liver or kidney planned pregnancy.

Side-Effects

Hypoglycaemia, the vision, pain in the abdomen, diarrhea, nausea, vomiting, constipation, increased liver enzymes, allergic reaction (itching, red skin rashes urticarnaya).

Patient interaction

Gipoglikemiceski effect increase MAO inhibitors, selective beta-adrenoblokatora, ACE inhibitors, salicilata, NPVS, oktreotid, alcohol and anabolic steroids. Gipoglikemiceski effect drug Novonorm reduce oral contraceptives, tiazidnye dioretiki, corticosteroids, danazol, tireoidnye hormones and simpatomimetiki. Together with the application ketokonazolom, itrakonazolom, eritromitinom, flukonazolom, mibefradilom upgradeable repaglinida concentration in plasma; Rifampitsinom fenitoinom and possibly lowering repaglinida plasma. Beta-adrenoblokatora may mask symptoms gipoglikemii.

Overdosing

Symptoms : development gipoglikemii (cold sweat, palpitations, tremor, a sense of hunger, excitement, irritability, paleness, headache, drowsiness, and about movements, the speech and vision depression). Treatment : sugar, or glucose inside (if the patient is in the minds of), n / a, in the / m or / in-glukagon or / in-glucose.

Precautions

Caution must be exercised in patients with liver disease or kidney, in the case of coming forward or surgical intervention, after recently suffered serious illness, including infectious. The weakened patients or human nutrition, and primary supporting dose should be kept to a minimum. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention, as Evolution gipoglikemii. There is a need to take into account the potential interaction with drugs mainly excretiruemami with jelchew.

Dosing and Administration

Inside for 85 minutes before the reception food. Dose selected individually. Typically, beginning treatment with doses of 0.5 mg. Improving it is not less than 1-2 weeks (depending on the level of glycemia). If a patient has another oral gipoglikemicescoe is recommended initial dose of 1 mg. The maximum single dose of 4 mg to major meals. The maximum daily dose should not exceed 16 mg.

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