Silubin retard

Roman name

Silubin # retard

The composition and the form of

1 tablet contains buformina hydrochloride 100 mg; blistere in 15 pcs. , in box 4 blisters.

Of drugs

Gipoglikemicescoe. Increases tissue sensitivity to insulino, reduces glucose intake of blood increases anaerobnyy glikoliz, glukoneogenez down in the liver.

Pharmacokinetics

Rapidly absorbed in the gut. Absorption is about 80%. C_max plasma-by 2.5 hours Report the news. T_1/2, 3-4 p.m.

Clinical pharmacology

Home of the 2-4 hour duration of about 8 hours

Indications

Aketonuriceski diabetes and excess weight, sugar insulinnezawisimy II diabetes type necorrigiruemy diet.

Contraindications

Hypersensitivity, insulinzawisimy diabetes, ketonuria, giperglikemical coma, pregnancy, lactation.

Side-Effects

Diarrhoeal disorders (loss of appetite, metallic taste in mouth, nausea, vomiting, diarrhoea), weakness, treatmentoptions.

Patient interaction

Gipoglikemiceski effect weaken derivatives fenotiazina (aminazin), corticosteroids, tireotropona hormones, estrogena, mochegonne reinforce, MAO inhibitors, antidiabetics sulfanilamida, salicilata.

Overdosing

There lactat-atidozom.

Dosing and Administration

Inside, at the time of delivery, ranging from 50 to 100 mg / day and then increased dose (but not more than 300 mg).

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