Siofor 500

Roman name

Siofor # 500

The composition and the form of

1 tablet coated liner contains metformina hydrochloride 500 mg (Siofor 500) or 850 mg (Siofor 850); blistere in 10 pcs. , in box 6 blisters.

Of drugs

Gipoglikemicescoe. Do glucose disposal muscles, delaying it (and other carbohydrates) induction of blood, glukoneogenez down in the liver, increases the sensitivity of tissues to insulino and reduces its inachtivirovnie.

Pharmacokinetics

Well drawn from the blood.

Farmakodinamika

Reduction of glucose in the blood. It is a significant reduction in body weight in patients with diabetes suffering from obesity, reduces appetite. And lipid and антифибринолитически ми properties.

Indications

Insulinnezawisimy diabetes mellitus (type 2), especially against the backdrop of obesity (with the poor of metabolic diet and physical load).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, insulinzawisimy diabetes mellitus (type 1), a complete cessation of endogenous secreting insulin diabetes type 2 (tolerance to child sulfonylureas) expressed human liver and kidney, cardiac and respiratory distress, the acute phase of myocardial infarction, chronic alcoholism, pregnancy, breast-feeding.

Side-Effects

Metal taste, nausea, vomiting, stomachache, diarrhea, allergic skin reactions.

Patient interaction

Compatible with derivative sulfonylureas, insulin weakens the effect of the proximity anti changes-zimetidina.

Overdosing

Symptoms gipoglikemii, development molernkislogo azidoza (depending on the selection of doses).

Precautions

Not recommended for use in acute infections, and worsening of chronic инфекционно-воспалит��льных diseases, trauma, acute surgical lesions in the body. Do not apply to the surgery or within 2 days after the election. Nor should appoint persons over 60 years of age or carrying heavy physical work (due to increased risk of molernkislogo azidoza). During treatment necessary to monitor kidney function. Be wary combine with indirect antikoagulyantami and zimetidine.

Dosing and Administration

Inside. Starting with a daily dose of 1-2 table. Ciofora 500 or one table. Ciofora 850 (equivalent to 0.5-1 g or 0.85 g metformina hydrochloride), and then it increased at intervals of a few days (Siofor 500), or from a few days to two weeks (Siofor 850) to the normal or higher daily intake - table 3-6. Ciofora 500 or Table 2-3. Ciofora 850. It should be borne in mind that typically increase doses does not result in a further increase efficiency. Pill Ciofora 850 can be divided into parts.

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