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The groupRational use of the funds for the cholesterol, LDL, triglycerides, and phospholipids, can have preventive and therapeutic effect of a host of diseases that affect the cardiovascular system.
Transmit cholesterol, phospholipids and triglycerides in the blood are lipoproteida, which according to their physico-chemical properties and physiological role divided into the following classes :
a) lipoproteida low density (quantum), transports, as a rule, cholesterol (cholesterol esters);
b) lipoproteida very low density (LPONP) perenoxiaschie mainly endogenous triglycerides;
c) lipoproteida high density (LPVP) perenoxiaschie primarily cholesterol, as well as cures.
Miscellaneous lipoproteida play different role in the development of atherosclerosis. LPONP transported endogenous triglycerides and cholesterol, finds cholesterol over the walls of blood vessels, that can contribute to the development of atherosclerosis, or an already existing process. LPVP, on the other hand, raise cholesterol from tissues, including the walls of the receptacles.
Therefore, the effect of lipid should be aimed not so much at reducing total cholesterol in the blood, how to reduce high-level engineers, and LPONP increase LPVP.
Synthesis and LDL cholesterol exchanges are complex biological processes, therefore influence them to a greater or lesser extent may regulators exchange of different pharmacological groups, including lipotropona means hormonal, unsaturated fatty acids (linetol, lipostabil) parmidin et al.
The main means of providing gipolipidemicescoe act are substances that bind jelchne acid-airing biliary acids (holestiramin, etc.) nicotine acid and its derivatives, statin (lovastatin, simwastin etc.), fibrata-derivatives fibroeva acid (klofibrat, bezafibrat etc.).
Typically, gipolipidemicakie funds are used in the integrated treatment of disease (particularly cardiovascular system), or result from lipid exchange.