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Omacor

See also Betaine

Roman name

Omacor

Characteristics

Contains polinenasyshchenne fatty acids Class omega-3-akozapentaenovu (EPC) and dokozagexaenovu (DGK) - irreplaceable (essenziale) fatty acids.

Pharmacokinetics

After intake omega-3 fatty acid metabolised in the liver, where they are included in the density of different classes and sent to the peripheral Stocks lipids. Most LCD oxidized to provide energy needs. Cures cell membrane phospholipids replaced density, and fatty acids act as precursors eikozanoidov different. Concentration LCD Class omega-3-EPC and DGK in fosfolipidah plasma concentrations of the EPC and DGK added to the cell membranes.

Farmakodinamika

Delays synthesis of triglycerides in the liver, as EPC and DGK hurt eterificaciu other fatty acids. Most of triglycerides also contributes to a decrease in the number of free fatty acids (increasing peroksisoma beta-okislenia fatty acids) for the synthesis of triglycerides. Inhibition of synthesis reduces the number LPONP.U patients гипертриглицеридемие й product adds certainty (low density polyethylene). While the LPVP increased very little unstable and significantly less than after taking Fibratov.vo treatment drug reduced synthesis tromboksana A2 and slightly increasing the drawdown. Expressed by changes in other factors such as blood clotting, however.

Clinical pharmacology

Observations (within 3.5 years) of the patients who have been on 1 g of the drug a day, showed a significant reduction in the combined rate, which includes deaths from all causes, heart attack and stroke stekardii without death.

Indications

Postinfarktnoe state (secondary therapy for the secondary prevention suffered myocardial infarction). Endogenic gipertriglitzeridemia : type IV (monotherapy); Type IIb / III (in combination with statins).

Pregnancy and lactation

Data on the use of drugs in pregnant women. Research on animals showed toxicity to the fetus and the mother body. Potential risk Omacor drug for humans is not known, and it is contraindicated for the period беременности.Несмотр�� the fact that data on a drug with breast milk is not to be taken during the period of breastfeeding.

Contraindications

Exogenously gipertriglitzeridemia (giperhilomikronemia Type I); Pregnancy and breast-feeding; гиперчувствительност ь to components of the preparation.

Side-Effects

Seldom-reaction from the stomach (reflux or burp with the smell or taste of fish, nausea, pregnant abdomen, diarrhoea or constipation), and eczema Akne.u patients гипертриглицеридемие й - modest increase liver transaminaz (AST and ALT).

Specific guidance

In theory gipertriglitzeridemy adopted in addition to the therapeutic feeding, unless the big actions are insufficient for the Reaktion.imetisa experience of the drug for treatment of secondary endogenous gipertriglitzeridemy (particularly when nepoddauschemsa control diabetes) is very limited.

Patient interaction

In connection with a moderate increase in bleeding time (to high doses, or 4 caps). Required to monitor patients receiving antikoagulyantnuu therapy, and, if necessary adjustments antikoagulyanta dose. Appointment with varfarinom does not result in a haemorrhagic complications, but the combination therapy, or in a reception Omakora ® needed to be monitored protrombinovogo Wremeni.net information on the combination with fibratami treatment гипертриглицеридемии .

Overdosing

Specific recommendations. Symptomatic therapy.

Precautions

It should take into account the increase in the time of bleeding in patients with high-risk gemorragii (as a result of severe trauma, surgery, etc.). Due to the lack of evidence of efficacy and safety of the drug is not recommended to appoint Detam.u patients with impaired liver (especially to the reception of a high dose Over all caps.) A regular monitoring of liver function (AST and ALT). Has no effect on the ability of the driving and maintenance of vehicles.

Storage conditions

With a temperature not exceeding 25 ° C (not freezing)

Shelf life

3 years

The registration

(OL)

The drug forms

Transparent, a soft, prodolgovataya, jelatinova capsule, filled with liquid light amber.

All products of this group

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