Thioctic acid

Chemical name

1,2-Дитиолан-3-пентанов��я acid (and in the form amide or sodium salt)

Gross

C8-H14-O2-S2

Characteristics

Brown crystalline powder gorkovatogo taste. Nerastvorim water (sodium salt rastvorima), and soluble in alcohol.

Of drugs

The drugs-gepatoproteguoe, desintoksikatine, gipoholesterinemicescoe, gipolipidemicescoe and antioxidant. Is kofermentom oxidative decarboxylation dofamine acid and alfa-ketokislot, normalizes energy, carbohydrate and fat exchanges, regulates cholesterol metabolism. Improves liver function reduces povrejdatee influence of the endogenous and exogenous Toksinov.posle reception inside quickly and adequately absorbed, C_max achieved after 50 minutes. Bioavailability is about 30% (by presistemna biotransformation). The liver and oxidized kongugiruet. Excreted news in the form of metabolites (80-90%) with T_1/2 20-50 min. Total plasma Cl-10 to 15 ml / min.

Indications

Coronary arteriosclerosis (prevention and treatment), liver disease (disease Hungary mild and severe, cirrhosis), polineiropatia (diabetic, etc.), the poisoning of heavy metal salts, etc. intoxication.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (for the period of treatment should stop breastfeeding).

Side-Effects

Violation of the metabolism of glucose (hypoglycaemia), allergic reactions (including anaphylactic shock); With the rapid on / in a short-delay or difficulty in breathing, increased vnutricerepnogo pressure, convulsions, diplopia, point bleeding of the skin and mucous, mitochondrial dysfunction.

Patient interaction

Do effects gipoglikemisiruth oral drugs and Insulina.nesovmestim Solutions periods and glucose compounds (including their solutions), responsive to disulfidnami and SH- groups or alcohol.

Overdosing

Symptoms : headaches, nausea, Rvota.lechenie : maintaining vital functions.

Precautions

Svetochuvstvitelen preparation. Ampoules from the packaging to be available only just before use. Solution for Infusion suitable for introduction during 6900, if protected from the effects of light.

Dosing and Administration

Inside (not liquid, squeezed small amount of water) to 480 mg once a day (morning), for the 2-4 and more weeks / with slow (at speeds of up to 50 mg / min), 480 mg in the form of infusions of physiological solution once a day for 2-4 weeks, then on the inside of 600 mg per day.

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