Tiogamma

Roman name

Thiogamma #

The composition and the form of

20 ml of 3% solution for injection contain tioktova acid 600 mg (as megluminova salt), in sealed dark glass to 20 ml, in a Box 5 or 10 ampul.50 ml of 1.2% solution for the infusions - tioktova acid 600 mg (as megluminova salt); Patients in the dark glass of 50 ml, cartons in one bundle, or 10 flakonov.1 tablet, film coated bullets, 600 mg; blistere in 10 pcs. , in box 3, or 6 blisters.

Of drugs

Gepatoproteguoe, desintoksikatine, gipolipidemicescoe, гипохолестеринемичес кое. Serves CoA role in okislitionom decarbauxilirovania alfa-ketokislot. Has reduce sugar content in the blood and increased levels of glycogen in the liver. The pharmacological properties tioktovaya acid near vitamins Group B.

Pharmacokinetics

Once inside quickly and almost completely absorbed from the digestive tract. Report the news, mostly in the form of metabolites formed by the oxidation of the side chain and kongugirovania. T_1/2 - 10-20 min.

Indications

Diabetic polineiropatia.

Contraindications

Hypersensitivity, saying disease stomach giperatidnyi saying, pregnancy, breast-feeding, child age under 18.

Side-Effects

From the nervous system and sensory organs : very rarely convulsions, diplopia (after in / introductions). From the circulatory system and blood (blood, gemostaz) : haemorrhagic skin (purpura), throm (after the / in введения).Аллергическ ие reactions : urticaria or eczema in the injection, systemic reaction until anaphylacticski Shoka.prochie : hypoglycaemia, neuralgia (with ingestion), the rapid introduction possible sense of gravity in the head, difficulty in breathing (to be).

Specific guidance

Alcohol weakens therapeutic effect tioktova acid.

Patient interaction

Do the insulin and oral gipoglikemicakih funds reduces the effect tsisplatina (r-r d / in.), with the molecules sugars is poorly soluble complex Soedinenia.r-r d / inf. incompatible with the glucose solution, and the ringer Solutions, which can react with Sh-groupami or disulfidnami ties.

Overdosing

Symptoms : nausea, vomiting, headache Bol.lechenie : symptomatic.

Precautions

Together with the use of insulin and oral gipoglikemicakimi means constant monitoring of blood glucose levels, especially in the early stages of treatment. In some cases, in order to avoid the development gipoglikemii requires a reduction in dose insulin or oral hypoglycemic agents.

Dosing and Administration

In / in the slow (20-30 minutes), in the form of infusions (r-r d / in. tentatively assigned in 50-250 ml of 0.9% physiological solution), 600 mg / day (1 USD 20 ml of 3% solution or one bottle of 50 ml). In applying bottles infusions produced directly from them, and made the suspension svetozashchitnye Cases. Course 2-4 Ned.vnutri not liquid, a small amount of liquid to 600 mg once a day (1 tab.) .

Storage conditions

r-r d / inf. : In the dark place at a temperature of 15-25 ° Cr-r d / in. : In the dark place at a temperature of 15-25 ° Cr-r d / in. : In the dark place at a temperature of 15-25 ° C. Packages to direct upotreblenia.tabl.p.o. : In the dark place at a temperature of 15-25 ° C

Shelf life

r-r d / inf. : 5 letr-r d / in. : 5 lettabl.p.o. : 3 and

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