Ursodeoxycholic acid

Chemical name

(3альфа,5бета,7бета)-3,7-Д игидроксихолан-24-овая acid

Gross

C24-H40-O4

Characteristics

White or slightly yellow powder. Nerastvorim almost in the water.

Of drugs

The drugs-jelchegonnoe, holelitoliticescoe, gepatoproteguoe, gipolipidemicescoe, gipoholesterinemicescoe, immunomodulirutee. Built in the spring gepatocita, stabilize its structure and protects gepatotit of damage factors. In holetaze activates Ca ^ 2 + -zawisimuu alfa-proteinzu and stimulates ackzozitos, decreases the biliary acids (holeva, litojoleva, dezoksiholeva etc.). Competitive ingibiruet induction lipofilnykh biliary acids in the gut, and increases their "faction" trafficking in enterogepaticescoy circulation, produces holerez, stimulates bile passage and down hills toxic acids through intestine. Quote nepoliarnae jelchne acid (henodeauxiholevu), which are mixed (non-toxic) micelles. Stops cholesterol synthesis in the liver. Treated with the cholesterol molecules liquid crystals and prevents its absorption in the gut, reduces холато-холестериновы�� index litogennosti bile; prevents holesterinovykh biliary stones and to the animals. Modulating the immune activity : it reduces the expression of histocompatibility antigen HLA-1 at gepatocitah and HLA-2 holangiocitah, activation zitotoksicnah cell, wherein "attack" immunocompetent immunoglobulins (primarily IgM). The ingestion well absorbed. C_max achieved through 0.5-1 hours The leg partially broken before litojoleva acid. Last exposed enterogepaticescoy circulation, and away from the liver, once again becoming a heno- and ursodezoksiholeve acid. Return with faeces.

Indications

Jelchnokamennaya disease, hepatitis (chronic, including atypical forms of autoimmune chronic, acute viral), nealkogolny steatogepatit, toxic (including alcohol, drugs) to liver, primary biliary cirrhosis and liver fibrosis, primary sclerosing holangit, atresia vnutripechenochnykh biliary tract and the holetaz Injecting food diskinesia psoriasis ways biliary refluks-gastrit and reflux-ezofagit; Opistorhoz chronic; preventing damage to the liver using hormonal contraceptives and drugs.

Contraindications

Hypersensitivity, acute inflammatory diseases of the gallbladder, biliary ERCP and bowel obstruction full biliary tract and obezazwestvljenne jelchne stones, cirrhosis being decompensation expressed by the human kidney, pancreas, pregnancy.

Side-Effects

Diarrhoea or constipation, nausea, pain in epigastralna area, and skin disease onset.

Specific guidance

Positive results can be obtained only if there is a holesterinovykh biliary stones (rentgenonegativeh), the size of not more than 15-20 mm.

Patient interaction

Antatsida and holestiramin reduce suction. Increases effect of oral antidiabetics funds.

Precautions

If long-term care is needed monthly monitoring of the level of liver transaminaz blood (especially in the first 3 months of therapy). The effectiveness of treatment should reaffirm study ray and ultrasound for psoriasis (every six months). In order to prevent the recurrence of holelitiaza should continue treatment for a few months after the dissolution of stones.

Dosing and Administration

Inside, at night (with liquid squeezed enough liquid). The dosage and duration of treatment are individually; Mean dose of 10 mg / kg / sut.

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