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UrsofalkSee also Ursodeoxycholic acidRoman nameUrsofalkPharmacokineticsAbsorbed in the intestine toshchei by passive diffusion, in the face of atherosclerosis, through active transport. The ingestion of one dose (500 mg) concentration in the serum after 30, 60 and 90 min of 3.8; 5.5 and 3.7 micromole per litre respectively. The methodical admission ursodeauxiholower acid (AST) is the main bile acid serum (48% of the total content of biliary acids). Included in the Gastrointestinal circulation. Terpevticheckaya drug effectiveness depends on the concentration of ALT in bile. While therapy is dozozawisimoe increase alone in the pool biliary acids to 50-75% (compared to a daily dose of 10-20 mg / kg). Passes through the placental barrier.FarmakodinamikaWith high polar properties versus non-toxic form mixed micelles with apoliarnami (toxic) jelcnami acids, which reduces the ability of the gastric refluktata damage cell membranes in biliarnom reflux-gastrite and reflux-ezofagite. Furthermore, AST is a double molecule that can be included in the cell membranes, stabilize them and make impervious to the effects zitotoksicnah micell. Decreases saturation hate spewed from the oppression of its absorption in the gut, suppress synthesis in the liver and lower secreta in mere; Increase the solubility of cholesterol in bile, forming its liquid crystals; Reduces litogenny index bile. The result is the dissolution holesterinovykh biliary stones and the prevention of the formation of new concrements. Immunomodulirutee the oppression of expression Hla-antigenov on membranes of hepatocytes and holangiotitov, normalization natural killerna lymphocyte activity, etc. reliably delaying the progression of fibrosis in patients with primary biliarian cirrhosis, cystic fibrosis and alcoholic steatogepathitom, reduces the risk of developing varicose veins expansion oesophagus.Clinical pharmacologyThe successful solution biliary stones, the stones were purely holesterinovmi, do not exceed 15 to 20 mm, and the gall bladder (completed at no more than half) and jelchevforodaschie ways to maintain its function.IndicationsPrimary biliary cirrhosis, primary sclerosing holangit, chronic hepatitis different etiology with signs of cholestasis, holesterinove jelchne stones in the gall bladder, biliary refluks-gastrit, biliary reflux-ezofagit, cystic fibrosis (cystic fibrosis liver), and toxic shock alcoholic liver cirrhosis, vnutripechenochny holetaz pregnant, holetsaticalkie liver disease in children (including biliary atresia ERCP) holetaz after liver transplantation, in holetaz Injecting food psoriasis psoriasis routes, a severe hepatitis, prevention of liver disease in the use of hormonal contraceptives and drugs, prevention of colon cancer in patients with high risk of development (for example, yazvennom kolite).ContraindicationsHypersensitivity, рентгеноположительны е (with a high content of calcium) jelchne stones functioning gall bladder, acute inflammatory diseases of the gallbladder, biliary ERCP and intestines, liver cirrhosis under decompensation expressed by the human kidney, liver, pancreas, pregnancy, breast-feeding.Side-EffectsDiarrhoea, nausea, pain in epigastralna area and the right podreberie, calzinirovnie biliary stones, the increase in the liver transaminaz, allergic Reaktion.pri treatment biliarnogo primary liver may occur passing decompensation cirrhosis, which disappears after the lifting of the preparation.Specific guidanceIn jelchnokamenna disease control effectiveness of the treatment, every six months by the hospital and ultrasonography psoriasis ways to relapse prevention holelitiaza. Treatment should continue for a few months after the dissolution of biliary stones. In holetsaticakih Hepatic should periodically determine transaminaz activity, alkaline phosphatase and гамма-глютамилтрансп��птидазы in the serum.Patient interactionHolestiramin, colestipol and antatsida containing aluminum hydroxide linked ursodeauxiholevu acid in the gut, preventing it from films and weaken the effectiveness of (simultaneous repair).OverdosingCurrently, the cases of drug overdose Ursofalk were reported.Storage conditionsList B. The temperature 18-25 ° CShelf life5 yearsThe registration014714/01-2003 |
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