Ciprofibrate

Chemical name

2-[4-(2,2-Дихлорциклопроп ил)фенокси]-2-метилпро��ановая acid

Gross

C13-H14-Cl2-O3

Of drugs

The drugs-gipolipidemicescoe. Does reduktazu гидроксиметилглутаро вого Koa violates education mevalonova acid (the intermediate product of steroids). Ingibiruet synthesis of cholesterol in the liver. Reduces total cholesterol and triglycerides in plasma; Adds LPVP reduces - LPONP and engineers, to lizisu fibrina and regression sukhojilnykh xantom (with the long-term применении).Достаточн о fully absorbed in the digestive tract. C_max achieved in 2 hours Firmly binds to plasma proteins. The liver and kidneys is compared with glukuronova acid. T_1/2-80 p.m. Place in unmodified form with urine or as a glukuronidov. Not koumouliruet.

Indications

Endogenic giperholesterinemia (isolated associated) and gipertriglitzeridemia not adjusted weekly and physically demanding; The risk factors NCEP.

Contraindications

Hypersensitivity, kidney, liver failure, pregnancy, breast-feeding (at the time of treatment are excluded), child.

Side-Effects

Headache, nausea, weakness, increased fatigability, myositis, mialgii, increased jelchnokamenna disease, increase whey transaminaz, creatinine, allergic skin reactions.

Specific guidance

Gipoalbuminemia necessitates reducing doses (matched individually).

Patient interaction

Incompatible with gepatotoksicskimi Programme (maleate perexillita, MAO inhibitors), magnifies the effect of proximity anticoagulants (antivitaminov K). Derivative nicotinic acid, etc. гипохолестеринемичес кие to maximize the impact of application.

Precautions

The inefficiency 3-6-mesyachnogo receive a combination therapy. At the time of treatment required careful monitoring of the level and activity of liver transaminaz : if activity savorotocna ALT exceeds 100 units. , Ciprofibrat overturned. Together with the appointment of indirect antikoagulyantami (under the supervision protrombina), it is recommended to reduce the dose by 30%.

Dosing and Administration

Inside, in the 100-200 mg per day.

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