Fenofibrate

Chemical name

2-[4-(4-Хлорбензоил)фено��си]-2-метилпропановой 1-metilatilovy acid ester

Gross

C20-H21-Cl-O4

Of drugs

The drugs-gipolipidemicescoe, urikozuricescoe, antiagregatine. Increases lipoproteinlipaza activity increases triglycerides catabolised in LPONP, accelerates the transition from cholesterol aterogennah LPONP in antiaterogenne LPVP, with the products LPONP declining. The tissues become active metabolite - fenofibroevu acid C_max plasma achieved in 5 hours After receiving an average concentration of 15 µ g / J Circulates in sossoudistom line at the albuminami. T_1/2 in the blood is about 20 hours Metabolised in the liver, appears mainly via the urine (fenofibrinova acid and its glukoronid) : up to 70% within 24 hours, up to 88% for 6 days. Cumulation not Nabludaetsa.u patients with hyperlipidaemia mixed reduces triglycerides LPONP and engineers, reduces by 25% the level of cholesterol engineers while the LPVP, especially LPVP_3 (33%), and in patients with only гипертриглицеридемие й declining levels at the outset, accompanied by a relative increase in cholesterol levels reasonable; in the long-term therapy in patients with hyperlipidaemia IIa and IIb observed decline in the total cholesterol by 16-29%, and triglycerides in type IIb by 30-60%. Reduces the highest levels fibrinoguena and uric acid in plasma; In the long-term therapy reduces ekstrawasculiarnae work.

Indications

Giperlipidemia types II, IV and V types and IIb and III of the ineffectiveness of diet, high cholesterol in the blood in the study of dynamic and / or its attendant risks (IBS, GB and complications).

Restrictions on the use of

Damaged liver function, including biliary cirrhosis, calkulezny holetsistit, severe kidney failure, alcoholism, pregnancy, breast-feeding (should abandon breastfeeding).

Contraindications

Гиперчувствительност ь.

Side-Effects

Cholelithiasis, the transaminaz and kreatinkinaza, nausea, vomiting, diarrhoea, mialgia, myofasciitis, rabdomioliz, acute renal failure, dizziness, headache, fatigue, impotence, skin irritation.

Patient interaction

Increases active anti proximity. Do gepatotoksicnosti pergexilina and MAO inhibitors. Gipolipidemiceski effect reduce oral contraceptives.

Precautions

There is a need to monitor the activity transaminaz; If the ALT twice or more, you mialgii and muscle weakness fenofibrat overturned. Treatment must be carried out for a long time, in combination with diet gipoholesterinova and under the supervision of a physician.

Dosing and Administration

Inside, 100 mg three times a day, mikronizirovanne form is 200 mg once a day.

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