Gemfibrozil

Chemical name

5-(2,5-Диметилфенокси)-2,2 -диметилпентановая acid

Gross

C15-H22-O3

Of drugs

The drugs-gipolipidemicescoe, гипохолестеринемичес кое. Normalizes away the blood plasma : Reduce the triglycerides LPONP increases-LPVP, especially LPVP_2 and LPVP_3 increases-apolipoproteida AI and apolipoproteida Sixth year. Ingibiruet peripheral lipolysis, to the development of liver free fatty acids and prevents long-inclusion atilov in the newly synthesized triglycerides (thereby reducing their synthesis in the liver), up turnover (disposal) cholesterol from the liver and stimulates it with the faeces. It absorbed by ingestion. T_1/2-1.5 hours Return, for the most part, aired in the form of metabolites.

Indications

Giperlipidemia IIb, IV, V types (on the Supreme Frederikson, 1967).

Restrictions on the use of

Breast-feeding (at the time of treatment should stop breastfeeding).

Contraindications

Hypersensitivity, violations of the liver and kidney (including primary biliary cirrhosis, jelchnokamennouu disease), pregnancy.

Side-Effects

Cholelithiasis, dizziness, drowsiness, parestesia, depression, headache, lower libido, impotence, impaired vision, mialgia, male, rabdomioliz, sinovita, artralgia, increased levels of AST, ALT, CPK, alkaline phosphatase, cium, lakopenia, anaemia, gipoplasia bone marrow, allergic reactions.

Patient interaction

Do anti effect (indirect). Incompatible with statins (lovastatin).

Dosing and Administration

Inside. Daily dose of 1200 mg divided into two parts and take 30 minutes before the morning and evening meals.

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