Colestyramine

Chemical name

Copolymer of styrene and divinilbenzola containing Quaternary ammonieve Group (as hydrochloride)

Gross

C22-H29-N-Ox

Of drugs

The drugs - гипохолестеринемичес кое. Links in the gut jelchne acid to form insoluble complexes removed from faeces. Decreases intake of fatty acids and cholesterol, stimulates synthesis of biliary acids from cholesterol in the liver (on the feedback). Impact of certainty and cholesterol in the blood, reduces nitrogen biliary acids in the proper skin. Patients who are гиперлипопротеинемие й Type II (especially type IIa) reduces the level of cholesterol and engineers. The partial obstruction psoriasis ways reduces the biliary acids in serum reduces their depositions in the dermal tissue and weakens the skin. Therapeutic effect manifests itself in the first month. To maintain the necessary long-term treatment. Prolonged use can disrupt digestion (intake of fats, vitamins A, D, K), causing bleeding (gipoprotrombinemia), and reduce the folic acid in the serum and erythrocytes.

Indications

Primary giperholesterinemia (increasing certainty), the prevention of atherosclerosis and its complications (including with coronary heart disease, myocardial infarct), itching with partial obstruction biliary tract.

Restrictions on the use of

Breast-feeding (optional waiver of breastfeeding).

Contraindications

Hypersensitivity, complete obstruction of psoriasis, phenylketonuria, pregnancy (and the suspicion it).

Side-Effects

Siegenia, pain and discomfort in the abdomen, leg high in the gut, nausea, vomiting, diarrhea, flatulence, anorexia, neuralgia, pancreatitis, steatorea, skin irritation, skin irritation, increased libido. Leaving the treatment-giperhloremiceski disorders, low blood coagulability gemorroidale bleeding, bleeding from the stomach ulcer, duodenal ulcer.

Patient interaction

Impact induction fenilbutazon, racumin, hlortiazida, tetracycline, penicillin G, phenobarbital, tiroksina, digitalisa (recommended these drugs through 4-6 h after administration kolestiramina).

Overdosing

The probable risk-occlusion syndrome.

Precautions

A periodic monitoring of the level of triglycerides, cholesterol and blood protrombina. During the treatment should be used more fluid.

Dosing and Administration

Inside the food (the contents of one paketika buskers in the cup, add water, milk or juice in the number of 60 to 80 ml, mix and wine after 10 minutes - that the powder adsorbiroval enough liquid and gel was homogeneous). Adults from 1 to 6 paketikov a day; Dosing children picked individually.

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