Atorvastatin calcium

Chemical name

[R(R*R*)]-2-(4-Фторфенил)-бе��а,дельта-дигидрокси-5- (1-метилэтил)-3-фенил-4- [ (фениламино)карбонил]- 1Н-пиррол-1-гептановой calzieva acid salt (2:1)

Gross

C66-H68-Ca-F2-N4-O10

Of drugs

The drugs - гипохолестеринемичес кое. Competitive selectively ingibiruet гидроксиметилглутари л-КоА (CoA) -reduktazu, turns 3 -гидрокси-3-метилглута рил-КоА in mevalonovu acid (predecessor sterolov, including cholesterol). Increase the number and increases Lpnp-retseptorov activity in the liver and stimulates the seizure, catabolised and stifles education engineers; Reduces their level in patients gomozigotna giperholesterinemiei family, including inefficiencies in lipid therapy Sredstwami.bystro skin. C_max achieved within 1-2 hours Bioavailability relative-95-99%, the absolute 12%, the system (for the inhibition G-koa-reduktaza) - 30%. Linking plasma protein at least 98%. The average of 565 litres. In the liver, with the participation of zitohroma P450 3A4 becoming ortho and парагидроксилированн ые derivatives and products beta-okislenia (70% inactivation G-koa-reduktaza comes from the metabolites). The concentration of plasma has improved in the face of alcoholic cirrhosis (blocked biotransformation). Return to jelchew. T_1/2-14 C.tormojenie G-koa-reduktaza a 20-30 hrs Most of the patients seen at the dose of 10 mg per day for 2 weeks, the greatest impact is the next week.

Indications

Primary giperholesterinemia combined (mixed) giperlipidemia, heterosexual and gomozigotnaya giperholesterinemia family (in addition to the diet).

Contraindications

Hypersensitivity, liver disease in the acute phase increased whey transaminaz (more than three times), pregnancy, breast-feeding, reproductive age women (at the time of treatment requires a reliable contraception).

Side-Effects

Nausea, neuralgia, aches, pains in the abdomen, constipation or diarrhoea, headache, insomnia, fatigue, mialgia.

Patient interaction

Increases plasma equilibrium concentration of digoxin, in the face of an oral contraceptive-levels and noretindron etinilestradiola. Erythromycin increases the content in the blood; Antatsida (containing magnesium and aluminium), holestiramin-less (but gipolipidemiceski effect of a combination with the latter exceeding that each product separately). The risk of myo increase ciclosporin, fibrata, erythromycin, niazin Fungicide (synthesis) drugs.

Precautions

Before starting and the period of treatment, it is necessary to maintain a standard гипохолестеринемичес кой diet. Be wary designate patients who misuse alcohol and / or suffering from liver disease (should constantly monitor its functions); If the level of AST and ALT more than 3 times that reduces dose or withdrawal from the market. Last necessarily in the development of myo (or even suspected it).

Dosing and Administration

Inside, regardless of the meal. One-to 10 mg / sut. Dose can be increased every four weeks to a maximum of 80 mg / sut.

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