Directory → Metaboliki → Lipid means → Statins → Cardiostatin
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CardiostatinSee also LovastatinRoman nameCardiostatinPharmacokineticsThe blood absorbed slowly and incompletely (30% of dose); Admission prandial reduces absorption by 30%. S_max is 2-4 h, and then the plasma is declining rapidly, at 24 h 10% of the maximum. Linking plasma protein-95%. Biotransformiroetsa the "first pass" through the liver with the formation of several metabolites, some of which are pharmacologically active (G-koa-reduktazu blocks). Passes through GEB and placental barrier. T_1/2 - 3h Report gastrointestinal (83%) and kidneys (10%).Clinical pharmacologyExpressed therapeutic effect seen within 2 weeks, and the maximum is four to six weeks from the start of the Lechenia.effectiven primary NCEP in patients neoslojnennam, offset insulinzawisimam (type 1) and insulinnezawisimam (type 2) diabetes mellitus.IndicationsPrimary giperholesterinemia high quantum type IIa and IIb, in the absence of the effect of diet and physical activity, combined giperholesterinemia and gipertriglitzeridemia, coronary atherosclerosis in patients with ischemic heart disease.Pregnancy and lactationContraindicated. At the time of treatment should stop breastfeeding.ContraindicationsHypersensitivity, liver disease in the acute phase, the increase in the liver transaminaz total heavy condition of the patient, pregnancy, breast-feeding, age and 18 years of age (the safety and effectiveness of the children have not been established).Specific guidanceIf this passes doses of the drug should be taken as soon as possible; If it is time to the next dose, dose not increase.Patient interactionDo antikoagulyantnoe the anti proximity and the risk of hemorrhage (a regular monitoring protrombinovogo time). Immunosuppressants (incl. ziklosporin) gemfibrosil, nikotinova acid, erythromycin increases the risk of rabdomioliza, acute renal failure. Fibrata, nikotinova acid Itraconazole and other means of containing the azolov increase the risk of developing miopati. Ciclosporin adds lovastatina metabolites in the plasma. Holestiramin and holestipol reduce bioavailability (application lovastatina possibly through 6700, once they are received, with the additive effect).PrecautionsBe wary when using liver diseases (in the disease), chronic alcoholism, organ transplantation, immunodepressivna concomitant therapy, chronic renal insufficiency, urgentnykh surgical manipulation (including dental). During the period of treatment to the standard diet low in the long Holesterina.pri therapy shows biochemical control of the liver : activity transaminaz determine before treatment, every 8 weeks during the first year of therapy, the "at least once in six months; with a daily dose of 80 mg-1 every 3 months. The resurgence of transaminaz (3 times the upper limit of), and raise the level of CPK product should отменить.Рекомендует��я treatment suspend or cancel preparation for the general serious condition Patienta.pri new pain in muscles, pain and muscle weakness should consult with a physician.Storage conditionsB. List in a dry, cool, the dark spotShelf life2The registration002573/01-2003 |
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