Lipostat

Roman name

Lipostat #

The composition and the form of

1 tablet contains sodium prawastatina 10, 20 or 40 mg; in a contour acheikova packing 14 pcs. (10 and 40 mg) and the contour acheikova packing 10 pieces in paper cartons 1 package (20 mg).

Of drugs

Gipolipidemicescoe. Competitive ingibiruet 3-гидрокси-3-метилглут��рил-КoA-редуктазу and stops cholesterol synthesis pre mevalonata education.

Pharmacokinetics

Rapidly absorbed, the average intake is 34%, absolute bioavailability 17%. Lipid effects similar to the reception along with the food or one hour before meals. Concentrations of the drug in plasma directly proportional to dose imposed. C_max in plasma is a 1-1.5 hrs In the steady state of the area under the curve (AUC), and C_max C_min no signs of the accumulation of a single or double administered in the course of the day. In the blood of 50% drug linked to the protein. T_1/2-half hours About 20% of the oral dose is with the urine and 70% in feces.

Farmakodinamika

Reduces the total cholesterol, cholesterol associated with the engineers and LPONP, apolipoproteida B, triglycerides increases cholesterol associated with LPVP and apolipoproteida A. Has tissue selectivity, the effect is manifested in the liver and lymph intestine.

Clinical pharmacology

The maximum effect is for 4 weeks.

Indications

Prevention of coronary heart disease in the face of NCEP to reduce the risk of myocardial infarction, the need for peace-revascularization attack, cardiovascular mortality; Giperholesterinemia (including inefficiency in diet), and in combination with гипертриглицеридемие й.

Pregnancy and lactation

Contraindicated in pregnancy. If pregnancy occurs during treatment, the admission should be discontinued.

Contraindications

Hypersensitivity, the worsening of liver disease nediagnostirovanne persistirute improving functional liver tests; Age (up to 18 years).

Side-Effects

Mialgia, miopatia (0.1%), rabdomioliz-isolated cases, the CPK, rashes on the skin.

Patient interaction

The effect of increasing the substance linking jelchne acid. Holestiramin co application reduces bioavailability (area under the curve of the concentration of 40-50%). Fibrata, ciclosporin, erythromycin, neuoqin increase the risk myo.

Precautions

Be wary appoint a host of diseases in liver disease and alcohol abuse. If you have muscle pain, pain or weakness (which may be a consequence of ingibitsii Koa-reduktaz) should immediately see a doctor. Admission should stop with a substantial increase in content and CPK suspected miopatiu.

Dosing and Administration

Inside, regardless of mealtimes, 10-20 mg once a day (at night). The original general holesterine more than 300 mg / m-40 mg / sut.

Storage conditions

table. : List B. In the dark water and ground at a temperature of 15-25 ° Ctabl. : List B. In dry place at room temperature

Shelf life

table. : 2 grams.

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