Directory → Metaboliki → Lipid means → Statins → Lovasterol
This page is translated automatically with a help of Google Translate
LovasterolSee also LovastatinRoman nameLovasterolThe composition and the form of1 tablet contains lovastatina 10, 20 or 40 mg; blistere in foil A1/PVC to 10 pcs. , in a cardboard bundle three blisters or polypropylene banks to 30 pc. (10 and 40 mg) and polypropylene banks to 28 pc. , in a cardboard one bundle Bank (20 mg).Of drugsGipolipidemicescoe, гипохолестеринемичес кое. The body is free beta-gidrokshikislotu that competitive ingibiruet G-koa-reduktazu and violates making profile in mevalonat, as a result of limited synthesis of cholesterol, increasing its catabolised reduced plasma level decreases the concentration of engineers, LPONP and triglycerides concentrations LPVP.PharmacokineticsWhen taken prandial intake reduced by approximately 30%. C_max is 2-4 hours Associated with blood plasma proteins by more than 95%. Penetrates through placental and blood-brain barrier. Treated hydrolysis in the tissues of several metabolites, including High бета-гидроксикислотн��го derivative. T_1/2 - 3h Write mainly gastrointestinal (about 83%) and kidneys (10%).Clinical pharmacologyFollowing the lifting of the continuing for a period of four to six weeks.IndicationsGiperholesterinemia primary (гиперлипопротеинеми�� type IIa and IIb), with no effect of diet, raised cholesterol, claimed in patients with a combination and giperholesterinemiei �ипертриглицеридемие��.Pregnancy and lactationContraindicated. A 89b2 t the time of treatment should stop breastfeeding.ContraindicationsHypersensitivity, heavy human liver resilient increased liver transaminaz in the serum, pregnancy, breast-feeding, age and 18 years of age.Side-EffectsFor part of the intestine : a 1% constipation, diarrhoea, digestive violations, slavery, the pain in epigastralna area flatulence, nausea; 0.5-1% vomiting, dry mouth, Vkusa.so violation of the musculoskeletal system : more than 1% muscle cramp, muscle pain; 0.5-1% pain in the lower extremities, in the area of the shoulder, joint pain, rarely miopatia, Rabdomioliz.so the nervous system and sensory organs : more than 1% dizziness, headache; 0.5-1% insomnia, Parestezii.so the skin : more than 1% skin rashes, itching of the skin; 0.5-1% Oblasenie.prochie : more than 1% of the violation, 0.5-1% pain in the chest, the weakening of sexual desire, increased liver transaminaz, alkaline phosphatase, cium, CPK in the serum.Patient interactionThe risk of myo increase immunosuppressants gemfibrosil, nikotinova acid, erythromycin, klaritromicin, ciclosporin, Itraconazole, ketonzol, protease inhibitors HIV. If you are receiving coumarin derivatives may increase protrombinovogo time holestiramina increased gipolipidemicski action.OverdosingSymptoms : perhaps the increasing incidence of side Daction.lechenie : symptomatic.PrecautionsThe appointment of a drug treated with diet, increased motor activity of the patient and lower body mass index. During treatment should observe bezholesterinovu diet. It periodically monitor the level of cholesterol, liver transaminaz in the serum. With the utmost care to apply severe renal failure and the violation of the liver and in patients with history of alcohol abuse. It periodically interrupt the treatment of heavy infections, arterial hypotension, extensive surgical intervention, trauma, severe metabolic, endocrine or elektrolitnykh violations and uncontrolled convulsions. The increase in CPK activity in the serum (10 times higher than the upper limit of), or in the case of myo product Otmeniti.neobhodimo should inform the doctor about all side effects (muscle pain, weakness, increased body temperature, health problems, etc.). Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.Dosing and AdministrationInside. Dose selected individually. Typically, the NCEP expressed at the beginning to 20 mg / day, with a moderate-to 10 mg per day once during dinner. Supporting dose, 80 mg / day, or one of several Priemov.na backdrop of immunosuppressants, 10-20 mg / day (maximum), with severe renal insufficiency (Cl creatinine less than 30 ml / min) - 20 mg / day (maximum).Storage conditionstable. : List B. In dry the dark place at a temperature below 25 ° CShelf lifetable. : 2 grams. |
All products of this group |