Directory → Metaboliki → Lipid means → Statins → Simgal
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SimgalSee also SimvastatinRoman nameSimgalThe composition and the form of1 tablet coated bullets simwastatina contain 10, 20 or 40 mg; in a cardboard unit 2 blisters to 14 pcs. or polypropylene containers to 28 pcs.Of drugsGipolipidemicescoe. Impact of plasma total cholesterol, engineers, LPONP, triglycerides increases, LPVP.PharmacokineticsThe blood absorbed 85% of the doses. The liver biotransformiroetsa in active бетагидроксиметаболи ты. Simwastatin and its metabolites associated with proteins to 95% is derived from jelchew (60%) and urine (13% of active metabolites).FarmakodinamikaГипохолестеринемичес кий effect develops in 2 weeks.IndicationsPrimary giperholesterinemia (with the poor diet), a combined and giperholesterinemia гипертриглицеридемия . In patients with ischemic heart disease and manifestations NCEP drug shown to slow progression of coronary atherosclerosis, reducing the risk of stroke and transient disturbance of cerebral circulation, reducing the likelihood of being peace-revascularization heart, reducing the risk of coronary mortality, and lower overall mortality.Pregnancy and lactationContraindicated.ContraindicationsГиперчувствительност ь (to any of the components of the drug or other drugs statinovogo a), liver disease in the active phase, the old transaminaz level in the serum, pregnancy, breast-feeding, age and 17 years of age.Side-EffectsFrom the nervous system and sensory organs : headache, dizziness, fatigue, Sna.so violation of the circulatory system and blood (blood, gemostaz) : arterial gipotenzia, eozinofilia, Trombozitopenia.so part of the intestine : constipation, diarrhea, loss of appetite, bloating, nausea, pain in the abdomen, the Pankreatit.so metabolism : to raise transaminaz, CPK, ALT, AST, alkaline фосфатазы.Аллергичес��ие reactions : urticaria, vasculit, volchanochnopodobnyy syndrome, angioneuroticeski swelling, Fotosencibilizace.prochie : miopatia, rabdomioliz.Patient interactionCiclosporin, erythromycin, and gemfibrosil nikotinova acid increases the risk of rabdomioliza and acute renal failure. Potenziruet proximity effect anticoagulants. Increases concentration of digoxin in plasma. Holestiramin reduces bioavailability.PrecautionsThroughout the course of therapy should be systematically monitored :-cholesterol concentrations in plasma (within 4 weeks from the start of treatment and then at regular intervals defined); - Pechenocnae samples (prior to the therapy, and for the first 3 months of treatment, with an interval of six weeks, continue over the next nine months, every eight weeks, and then about every six months); if the transaminaz exceeds three times exhibition cancelled; is the level of CPK (CFC) in the blood plasma in patients with a host immune or niazin, as well as in the case of myo; when CFC begins to exceed the norm by 10 times, drug Otmenaut.s appoint caution : patients who misuse alcohol and / or have a history of liver disease; after organ transplants, in immunodepressivna therapy (at the risk of rabdomioliza and kidney failure); , in the states, which can be expressed by the development of renal insufficiency (arterial gipotenzia, severe acute infectious diseases, expressed metabolic and endocrine, vodno-elektrolitny imbalance surgery (including dental), or injury).Storage conditionstabl.p.o. : List B. In the dark place at a temperature of 10-25 ° CShelf lifetabl.p.o. : 2 grams. |
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