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SimvorSee also SimvastatinRoman nameSimvorCharacteristicsSimvor tablets 5 mg-yellow pills oval coated films coated with <SST> etched on the same side and <5> at Druga.simvor tablets 10 mg-pills svetlo-rosove oval coated films liner with <SST> etched on the same side and <10> at Druga.simvor tablets 20 mg tablets, peach-coloured oval coated films coated with <SST> etched on the same side and <20> at Druga.simvor 40-mg tablets pink oval-shaped, film coated liner with <SST> etched on the same side and <40> on another server.PharmacokineticsAfter intake of readily absorbed. C_max plasma achieved through 1,3-2,4 h is reduced by 90% after 12 hours Linking plasma protein is 95%. Metabolised in the liver, has the effect of the first pass through the liver (mainly hydrolyses education metabolita active-beta-gidrokshikislota, other active and inactive metabolites). T_1/2 active metabolites is 1.9 C.vwoditsa mainly to the masses of urine (60%) in the form of metabolites, about 10-15% in the kidneys inactive form.IndicationsPrimary giperholesterinemia IIa and IIb type (with inefficiency nutrition in patients with increased risk of coronary atherosclerosis), combined giperholesterinemia and gipertriglitzeridemia, hyperlipoproteinemy not easily correction special diet and physical load.Pregnancy and lactationContraindicated (security and the effectiveness of the unknown).ContraindicationsГиперчувствительност ь to components of the drug and other drugs statinovogo stimulants (inhibitors G-koa-reduktaza) in the disease, liver failure, acute liver disease, the increase in the liver transaminaz ambiguous genesis, pregnancy, the period of breast-feeding, age and 18 years of age (the safety and effectiveness of the unknown).Specific guidanceBefore treatment to a study of the liver and then monitor activity transaminaz liver every six weeks for the first 3 months, then every 8 weeks for nine months remaining first year, then every 6 months. Patients receiving simwastatin dose of 80 mg / day, the liver over every three months. Where transaminaz activity increases, and only three times the upper limit rules Otmenaut.u treatment of patients with mialgiei, myasthenia and / or expressed growing activism kreatininfosfokinaza drug treatment прекращают.Симвастат��н (like other inhibitors G-koa-reduktaza) should not be applied to the increased risk of rabdomioliza and renal failure (in the face of severe acute infection, arterial hypotension, a planned surgery, trauma, severe metabolic disturbance). The removal of lipid during pregnancy does not have a significant impact on the long-term treatment of primary �иперхолестеринемии.В �back to the fact that inhibitors G-koa-reduktaza down cholesterol synthesis and cholesterol and other products of his house to play an essential role in fetal development, including synthesis of steroids and cell membranes, simwastatin can have adverse effects on fruit in the appointment of his pregnant women (women of childbearing age should avoid conception). If the treatment is pregnancy, the drug must be cancelled and patients warned of the possible danger to Ploda.simwastatin not shown when there is gipertriglitzeridemia I, IV and V Tipov.preparat effective in the form alone, or in combination with biliary sekwestrantami Kislot.do to and during the course of treatment the patient should be gipoholesterinova Diete.patientam with severe renal failure treatment are under the control of the Pocek.patientam should be reported to a doctor about unexplained pain in the muscles, lethargy, weakness, particularly if accompanied by malaise and fever.Patient interactionDo the anti proximity and increases the risk of hemorrhage. Is increase in the concentration of digoxin in plasma Krovi.zitostatiki, antifungals (ketokonazol, Itraconazole) fibrata, high doses of nicotinic acid, immunosuppressants erythromycin, klaritromicin, protease inhibitors increase the risk of developing рабдомиолиза.Колести��амин and colestipol reduce bioavailability (application simwastatina possibly through 6700 after taking the drug, with the additive effect).PrecautionsBe wary designate patients who misuse alcohol and / or have a history of liver disease, patients who after organ transplantation therapy is immunodepressantami (as a result of the heightened risk of rabdomioliza and kidney failure); For conditions that could lead to failure expressed by the kidney, such as arterial hypertension, acute infectious diseases heavy currents expressed metabolic and endocrine disruption, violations �одно–электролитного �alansa, surgery (including dental), or injury; patients with low or high tone skeletal muscles unclear etiology; with epilepsy.Storage conditionsB. List in a dry place so that the temperature does not exceed 25 ° CShelf life2The registration011797/01-2000 |
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