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Vasilip

See also Simvastatin

Roman name

Vasilip

The composition and the form of

1 tablet coated liner contains simwastatina 10, or 20 mg; in a contour acheikova package 7 pc. , in a cardboard unit 2 or 4 packaging.

Of drugs

Gipoholesterinemicescoe, gipolipidemicescoe. Ingibiruet Gmgkoa reduktazu participating in biosynthese cholesterol in the liver. Lowers the total cholesterol, engineers, LPONP and triglycerides and increases-LPVP. Improves the endotelia inhibits growth and migration of cells in cattle, has an antioxidant effect.

Pharmacokinetics

Well drawn from the blood. The first passage through the liver to 76% is transformed into an active form. Return to jelchew and faeces.

Farmakodinamika

The effect is two weeks and reaches its peak for 4-6 weeks.

Indications

Primary giperholesterinemia type IIa and IIb (monotherapy with inefficiency diet and other treatments), ischemic heart disease (to reduce the risk of myocardial infarction and death).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, liver disease in the active stage, the old transaminaz level in the serum unclear etiology, porphyria, pregnancy, breast Grudew.detski age (safety and efficacy of the use of children to be determined).

Side-Effects

From the nervous system and sensory organs : a sense of fatigue, dizziness, headache, insomnia, in some cases, depression, peripheral neiropatia, clouded Hrustalica.so part of the intestine : nausea, vomiting, flatulence, constipation or diarrhoea, neuralgia, pain in the abdomen, increased liver Fermentov.prochie : muscle weakness, alopecia, itching. In some cases, the functions of the kidneys, proteinurija, impotence, miopatia, rabdomioliz, dermatomiozit, skin rashes, eczema.

Patient interaction

Do proximity effects and anti-digoxin. Incompatible with ziklosporinom, derivative fibroeva acid, niacin, eritromitinom, klaritromitinom, ketokonazolom, itrakonazolom (perhaps the myo, rabdomioliza and kidney failure). Ritonavir enhances simwastatina concentration in the blood.

Overdosing

Treatment : induction vomiting, the appointment of activated carbon, monitoring of the liver, kidneys, respiratory system, cardiovascular system and kreatinkinaza content in the serum.

Precautions

Be wary appoint patients with liver diseases in history, consuming large quantities of alcohol. During the period of treatment to monitor the level of liver enzymes and kreatinkinaza.

Dosing and Administration

Inside, the initial dose of 10 mg once a day for primary prevention, secondary prevention-20 mg, if necessary dose can be increased to 40 mg.

Storage conditions

tabl.p.o. : List B. The temperature is not above 30 ° C

Shelf life

tabl.p.o. : 2 grams.

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