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Zocor

See also Simvastatin

Roman name

Zocor

The composition and the form of

1 tablet contains simwastatina 10, 20 or 40 mg, one tablet, coated bullets, 80 mg; in a contour acheikova packing 14 pcs. , in box 1 or 2 packaging.

Pharmacokinetics

Quickly extracted from the blood in the first passage through the liver, with a high selectivity to accumulate it appears to jelchew. The active form of systemic blood-less than 5% of the dose; Associated with a protein of 95%.

Clinical pharmacology

Impact of plasma total cholesterol, engineers, LPONP, triglycerides; Adds LPVP. Effect develops over two weeks and reaches its peak in 4-6 weeks. Upon separation therapy cholesterol returned to the original level.

Indications

Giperholesterinemia, ischemic heart disease, arteriosclerosis cerebrovascular. Reducing the risk of a common and coronary mortality in patients with ischemic heart disease.

Pregnancy and lactation

When pregnancy is contraindicated. Breast-feeding at the time of treatment is not recommended.

Contraindications

Гиперчувствительност ь (to any of the components of the drug), liver disease in the active form, reaching the level transaminaz in plasma unclear etiology.

Side-Effects

Headache, dizziness, fatigue, neuralgia, hepatitis / jaundice, pancreatitis, stiffness in muscles, mialgia, miopatia, rabdomioliz, parestesia, peripheral neiropatia, anaemia, alopecia, skin rashes, itching, the reaction гиперчувствительност и (urticaria, photosensitization, fever, hyperemia skin, shortness of breath, malaise, swelling angioneuroticeski, volchanochnopodobnyy syndrome, Medicine polimialgia, vasculit, arthritis, artralgia, improving Monday, thrombocytopenia, eozinofilia); deviations in laboratory performance (more transaminaz, alkaline phosphatase, gamma-glutamiltranspeptidaza, CPK skeletal muscles, changes in the functional liver samples).

Patient interaction

Moderately potenziruet effect kumarinovykh anticoagulants. When combined with ziklosporinom, itrakonazolom, ketokonazolom, derivative fibrinova acid, niacin, eritromitinom, klaritromitinom, protease inhibitors, nefazodonom increased risk of rabdomioliza. Treatment should be discontinued if confirmed or suspected presence of myo.

Overdosing

In several known cases of overdose (maximum dose of 450 mg); Revealed no specific symptoms or effects. A symptomatic treatment.

Precautions

Before treatment is recommended (and then periodically repeat), a study of the liver. When the transaminaz beyond normogranitsu top three times, preparation repeal. Be wary designate patients who misuse alcohol and / or have a history of liver disease.

Storage conditions

List B. The temperature is not above 30 ° C

Shelf life

3 years

The registration

013094/01-2001

All products of this group

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