Alfacalcidol

Chemical name

(1альфа,3бета,5Z,7E)-9,10-Се��охолеста-5,7,10(19)-триен- 1,3-диол

Gross

C27-H44-O2

Characteristics

Vitamin Group D. The white crystalline powder, insoluble in water, soluble in alcohol, ether, chloroform, plant oils. Sensitive to the effects of light, oxygen, air, etc. oxidizing factors.

Of drugs

Drugs, the governing calzi-fosfornyi exchange. Jirorastvorimy vitamin. Plays an important role in the maintenance of homeostasis calzievogo and phosphorus exchanges. Increase intake of calcium and phosphate clearance of the small bowel, and their concentration in the blood. Decreases osteomaliatia and contributes to the mineralization of bone tissue. Reduces content in the blood paratgormona. Once inside quickly and completely absorbed in a thin leg. C_max in the blood is 12 hours The blood binds to a specific alfa-globulinami and transported to the liver, which is transformed into an active form 1,25-дигидроксихолекал��циферол. Duration of up to 48 hours. Metabolised in the kidneys. Products biotransformation excretiruyutza with urine and jelchew (roughly the same ratio).

Indications

Rickets, renal osteodistrofia, gipoparatireoz, giperparatireoz with osteomalaciei, tetania, osteoporosis (senilny against the backdrop of the admission of glucocorticoids), gipocalziemia, gipofosfatemia.

Restrictions on the use of

Atherosclerosis, disruption of the liver and kidney.

Contraindications

Hypersensitivity, gipercalziemia, giperfosfatemia, gipervitaminoz D, pregnancy, breast-feeding (to be filed).

Side-Effects

Siegenia or diarrhea, xerostomia, reduced appetite, metallic taste in mouth, nausea, vomiting, decrease in body mass index, increased fatigability, suffering, pain in the bones and muscles, hypertension, arrhythmia, headache, polideepcia, polinictoria, refers.

Patient interaction

Anti preparations gidantoin, barbiturates, holestiramin, mineral oils reduce the effect. When coupled with the antatidami is giperaluminemia and gipermagniemia; The potential for spin-off properties growing at a tiazidnykh dioretikov, calzi- and containing substances cardiac glycosides.

Dosing and Administration

Inside. Adults - initial dose 1 g / day, could rise to 0.5 g every 2-4 weeks to 2 (in a few cases up to 3) µ g / day; Supporting dose-0,25-1 µ g / day, the children - 0.25 µ g / sut.

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