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BondronatSee also Ibandronic acidRoman nameBondronatThe composition and the form of1 USD 1 ml concentrate preparation infusions contains 1.125 mg ibandronova odnonatrieva acid monohydrate salt, the 1 mg ibandronova acid; in blister packs in a carton 5 pcs.Clinical pharmacologyIncreases bone mass. Effective in the treatment of osteoliticescoy gipercalziemii caused by malignant neoplasms and gumoralna gipercalziemii. In most cases, a single cefuroxim bondronata leads to the normalization of calcium levels in the serum and prevents gipercalziemii relapse in the next few weeks.IndicationsGipercalziemia in malignant tumors (with or without Metastases).ContraindicationsHypersensitivity expressed renal insufficiency (serum creatinine> 442 micromole / l), pregnancy, lactation (for the suspension breastfeeding), children's age (no experience clinical application).Side-EffectsGrippopodobnyy syndrome, a decline of renal excretion of calcium gipocalziemia, reducing the whey phosphorus, diarrhoea disorders.OverdosingAt present time reports of acute overdose Bondronata lacking. Since preclinical studies high dosage to a toxic effect on the liver and kidneys, with a possible overdose, it was necessary to monitor the function of these organs. Clinically significant gipocalziemia be remedied by on / in the glukonata calcium.PrecautionsA sufficient degree of hydration, close monitoring of kidney whey levels of calcium and magnesium, as well as compliance with the precautionary principle in the appointment of people with гиперчувствительност ью from other bifosfontam. Not recommended / a and d / to the introduction (because of the potential damage to the surrounding tissue).Dosing and AdministrationIn / in in the form of infusions, in the two hours (tentatively contents sealed diluted in 500 ml of solution izotoniceski sodium chloride or 5% glucose solution). Dose set individually, depending on the extent gipercalziemii and type of tumor. When expressed gipercalziemii (RNA levels of calcium, adjusted for RNA albumin-3 mmol / L or 12 mg% or more), a single dose of 4 mg; At a moderate gipercalziemii (calcium level less than 3 mmol / l) for the 2 mg. The maximum dose of 6 mg. The possible re cefuroxim through 18-19 days.Storage conditionsList B. In normal conditions. After cooking, with a temperature of 2-8 ° C for 24 hShelf life5 yearsThe registration013021/01-2001 |
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