Clodronic acid

Chemical name

(Дихлорметилен)бисфос фоновая acid

Gross

C-H4-Cl2-O6-P2

Of drugs

The drugs-ingibirutee bone resorption. Normalizes the content of calcium in the bone. Suppress activity Osteoclastov.ploho extracted from the blood (about 2% of dose). Simultaneous food or drugs affects calcium absorption. The high concentration accumulates in the bones. There is a two-phase kinetics : T_1/2 in the first phase (withdrawal of plasma) - 2 hrs, in the second (down from the bone), to several years. About 80% of output with urine in the first few Dnei.izbiratelno affects bone tissue. Decreases severity controlling pain in osteoporosis and metstaticescom defeat bones. Effectively reduces the level of calcium in the blood plasma, preventing the development of clinical signs and gipercalziemii gipercalziemicescoy coma. When treating osteoporosis increases the mass of bone by the end of the first year of therapy, particularly in the spine. Alternatively, гормонозаместительно й therapy can be used in postmenopauzne osteoporosis. In overdose osteoblasta threatened and violated mineralization bone (osteomalacia).

Indications

Osteoporosis osteoliz and as a result of elevated rezorbtion bone (neoplasia, and metastatic), gipercalziemia in malignant tumors.

Contraindications

Гиперчувствительност ь.

Side-Effects

Seldom-neuralgia, a violation of kidney proteinurija, increased creatinine, increased activity alkaline phosphatase, a small gipocalziemia.

Specific guidance

It should not be applied at the same time other bifosfonata.

Patient interaction

Medicinal calcium, iron, antatsida reduce effectiveness. Aminoglikozida could lead to gipocalziemii expressed.

Overdosing

Symptoms : increased creatinine in the serum, gipocalziemia (with the clinical symptoms and without them). After the preparation of calcium in the plasma returned to within 4 days.

Precautions

Caution must be exercised with on / in the introduction patients expressed renal insufficiency (recommended reducing the dose). When side effects from the stomach needs adjusting doses. Showed regularly monitor the level of calcium in blood plasma. In developing gipocalziemii recommended short break in treatment. During therapy to limit the use of products rich in calcium (milk, cheese, cabbage, lettuce, zucchini, apricots, strawberries, lemons). Medicinal calcium (shown) should not be taken concurrently with claudronova acid (required 1-2-casova interval).

Dosing and Administration

Inside, in / in the drip. In heavy gipercalziemii and strong pain in the bones to start with on / in (drip), a drug-3-5 mg / kg for three to five days to the transition to oral ingestion. In mielomna disease 1,6-2,4 g / day inwards breast cancer-2.4 g / day of the continuous decrease dose to 1.6 g / d, cancer prostate-1,6-3,2 g / sut.

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