Colecalciferol

Chemical name

(3бета,5Z,7E)-9,10-Секохоле��та-5,7,10(19)-триен-3-ол

Gross

C27-H44-O

Characteristics

The white crystalline powder. Nerastvorim in water, soluble in alcohol, ether, chloroform, plant oils. Maloustoichiv action light, easily oxidized.

Of drugs

Drugs, the governing calzi-fosfornyi exchange. Do intake of calcium in the gut and reabsorbqiyu phosphorus in the kidney Channel, normalizes a bony skeleton and teeth in children contributes to the conservation of the bones. Increases permeability and cell membranes muthondrialnah intestinal epithelium by facilitating crezmembranny cation transport calcium and other dwuhvalentnykh cations, activates secondary phosphate intake increases the seizure of these ions bone tissue, strengthens the ossification. Absorbed in the department distalnom small bowel (to the presence of bile), is the lymphatic system, is in the liver and to the overall flow. The blood contact alfa_2-globulinami and partly from albuminami, has been postponed in the liver tissue, bones, skeletal muscle, kidney, napochechnikov, attack jirovu fabric. C_max in tissues through a 4-5 h after the introduction, and then slightly down, persisting long time constant. In a polar metabolites localized mainly in the membranes of cells mikrosom, mitochondrial and nuclear. Deposited in the liver. The biotransformation in the liver and kidneys are active metabolites. Most kolecalziferola and products exchange is the jelchew in intestine, from which they may be re-possessed by creating a enterogepaticescoy circulation, or excretirovtsa with faeces.

Indications

Rickets (prevention and treatment), spazmofilia, osteomalacia, metabolic osteopathy (gipoparatireoz, psevdogipoparatireoz) gipocalziemia, tetania, osteoporosis, reduced bone education sore (with fractures), the loss of calcium in bones and teeth.

Restrictions on the use of

Organic heart failure, acute and chronic liver disease and kidney disease syndrome, a disease hospital of stomach and duodenal ulcers, pregnancy, hypothyroidism, old age.

Contraindications

Hypersensitivity, gipercalziemia, gipercalziuria, calzievy nefrourolitiaz, prolonged immobilization (high dose), the active form of pulmonary tuberculosis.

Side-Effects

Headache, gastrointestinal disorders, kidney irritation, aggravation of TB in the lungs.

Specific guidance

The preventive application, it is necessary to bear in mind the possibility of an overdose, especially among children (should not appoint more than 15 mg per year). During treatment required control of calcium in the blood and urine (particularly when coupled with tiazidnami dioretikami).

Patient interaction

Effect reduce difenin, holestiramin toxicity - vitamin A. Speed biotransformation increase barbiturates.

Overdosing

With high sensitivity and an overdose can occur gipercalziemia, gipercalziuria and symptoms of the resulting violations of heart rhythm, nausea, vomiting, headache, weakness, irritability, lower body mass index, a strong thirst, frequent urination, education kidney stones, nefrocalzinoz, calzinoz soft tissues, anorexia, arterial hypertension, constipation, kidney failure. In chronic poisoning-Demineralisation bone calcium deposition in the kidneys, blood vessels, heart, lungs, gut, the violation of the bodies, which can lead to death Ishodu.lechenie : kolecalziferola removal, the appointment of corticosteroid, vitamin E, magnesium products, potassium, ascorbic acid, retinol, thiamine.

Dosing and Administration

Inside, with a minor daily intake - 1000-2000 IU. The / m-200 IU. To prevent rickets - 200000-400000 IU every 6 months (up to 5 years). Treatment rickets, and spazmofilii gipocalziemii-200 IU per week for 2 weeks (with the addition of calcium salts); Osteomalation and osteoporosis-200 IU every 15 days for 3 months. To prevent attacks tetanii appointed to the 1000 IU per day.

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