Dihydrotachysterol

Chemical name

(3бета,5Е,7Е,10альфа,22Е)-9, 10-Секоэргоста-5,7,22-три��н-3-ол

Gross

C28-H46-O

Characteristics

Clear crystals or white crystalline powder. Virtually nerastvorim in water, soluble in alcohol.

Of drugs

The drugs-D-vitaminopodobnoe governing calzi-fosfornyi exchange. Has increased intake of calcium in the gut, strengthens the mobilization of phosphorus organic compounds bone and elevating it Pockami.podvergaetsa gidrauxilirovaniu in liver education 25-gidroksidigidrotahisterola, which is the main active metabolite circulating in the blood and is not subject to further Okisleniu.pri violation fosfor-calzievogo exchange rate stabilizes calcium and connects it to the bone, preventing osteoporosis. Active in ingestion, it is slow and prolonged effect can be used for a long time without the development of tolerance. With long-term use of high doses can gipercalziemia and violation fosforno-calzievogo balance in the tissues of the gastrointestinal tract, the increase reflected sokratimosti. In appointing during pregnancy was early calcification fruit.

Indications

Under secreta paratgormona : gipoparatireoz (autoimmunny, posleoperazionny after treatment radioactive iodine trauma, as sarcoidosis or tuberculosis, Cancer); Functional gipoparatireoz (low secretia paratgormona in response to gipocalziemia) : infants born to mothers with gipoparatireozom; Idiopathic neonatal gipocalziemia; Gipomagniemia (malabsorbece, vomiting and diarrhoea steatorea, diabetes mellitus, acute pancreatitis, alcoholism); a lack of vitamin D (alimentary deficit, a lack of UV rays malabsorbece, steatorea, syndrome short bowel, chronic pancreatitis, spru); peripheral resistance paratgormonu : psevdogipoparatireoz (Olbreita syndrome); chronic renal failure (kidney osteodistrofia); gipocalziemia atrogenna Nature : giperfosfatemia (including food genesis); Appointment of large doses of EDTA, mitramitina, aktinomitina, neomitina, bifosfonatov, tiazidnykh dioretikov, prolonged use of laxatives, phenobarbital, etc. protivosudorozhnykh funds calzitonina overdose; Robust transfuzia zitratna blood operation in the extracorporeal blood circulation.

Contraindications

Gipercalziemia, pregnancy.

Side-Effects

Paleness, headaches, dizziness, weakness, palpitations, thirst, diarrhoea disorders (loss of appetite, nausea, vomiting, diarrhea), the pain in the right podreberie caused reductions gall bladder, the kidney functions, cardiosclerosis, pnevmoskleros, nefroskleros (with the long-term use).

Patient interaction

Is a rational combination with drugs calcium. Incompatible with other drugs vitamin D. Tiazidnye dioretiki promote gipercalziemii. Not recommended combination with fenoterolom.

Overdosing

Symptoms : increased side effects associated with gipercalziemiei. The emergence of mud, amnesia, disorientation, hallucinations sincopalnah states hypotonia, gipercalziemicescoy Koma.lechenie : the immediate withdrawal of the drugs, bed rest, drinking fluids, diet low in calcium, the appointment of laxatives and dioretikov loop in / in a physiological solution Corticosteroids, zitratov, sulphate, phosphate, EDTA, mitramitina; To the kidney.

Precautions

To prevent gipercalziemii a regular monitoring of calcium and phosphorus in the blood and urine. Recommended a diet with a high content of food calcium and low-phosphorus. In patients with gipotireozom in treatment tireoidnami hormones and receiving digidrotahisterol, lifting the last to be carried out with caution because of the risk gipercalziemii.

Dosing and Administration

Inside. Dose prepared individually, depending on the extent gipocalziemii and is 0.8-2.4 mg / sut.

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