Don

Roman name

Dona

The composition and the form of

1 package (160g) powder for solution for the reception inside the glukozamina sulfate 1.5 g; in a box 20 st.1 capsule 250 mg; in a box 80 st.1 USD 2 ml solution for injection 400 mg; in a contour acheikova package 6 vials of the drug (morphine A) together with the solvent in the USD 1 ml (mg B), in a cardboard bundle 21.90.

Characteristics

Glukozamina sulphate is a natural component of joint cartilage, physiologically present in the human body. Represents aminosa ff9 harid low molecular weight, has been cleaned of macromolecular components.

Of drugs

Hondroproteguoe, antiinflammatory, analgezirutee, catalytic regeneration cartilage tissue anabolicescoe, antikatabolicescoe. Fills monetary deficit glukozamina sulfate. Glukozamin stimulates synthesis hondrozitami protheoglicanov (glukozaminoglicanov and hyaluronic acid) virus liquid; Ingibiruet enzymes (kollagenzu, fosfolipazu A2, etc.), destruction of cartilage tissue; Hinders superoksidnykh radicals, suppresses activity of lysosomal enzymes; , A process sulphur fixation in the synthesis hondroitinserna acid and to the normal deposition of calcium in bone; povrejdatemu preclude action on corticosteroid hondrozita and violation synthesis glikozaminoglikanov, induzirovannomu Npvs.sulfogroup also involved in the synthesis of glikozaminoglikanov metabolism and cartilage tissue, but sulfoefira side chains of protheoglicanov by promoting water retention in maintaining elasticity matrix Hrashcha.glukozamina sulfate halts cartilage degradation and reduces symptoms in osteoartroze.

Pharmacokinetics

Quickly and completely absorbed in a thin leg. After the / m, and the reception inside easily transcends biological barriers and penetrates the tissues, mainly joint cartilage. T_1/2-68 p.m.

Farmakodinamika

Clinical improvement is usually two weeks after the start of treatment, while in the / m introduction through 3-4 days and maintained for a period of 8 weeks after the preparation that allows for intermittent courses.

Indications

Prevention and treatment osteoartroza various sites (knee, hip, powers joints, the spine, etc.).

Pregnancy and lactation

Data on the use of drugs during pregnancy and lactation are not available.

Contraindications

Hypersensitivity, phenylketonuria (for powder, as it contains aspartame). Solution for injection contains support component, lidocaine, and he is contraindicated patients with serious cardiac conductance and ff9 acute heart failure, as well as with гиперчувствительност ью lidokaino to.

Side-Effects

On rare occasions, there gastrointestinal disorders slightly and transitory nature, allergic reactions (urticaria); Extremely rare form of injection can cause headaches, vision problems (because of the presence of lidocaine).

Specific guidance

No data on the use of the drug in children under 12 Let.preparat compatible with NPVS and glukokortikoidami.

Precautions

Solution for injection with caution appoint patients with severe chronic heart failure and arterial gipotenziei.

Dosing and Administration

Powder : inside for 20 minutes before food, the contents of one paketika dissolved in 200 ml of water and take once a day for 12 weeks. Courses can be repeated at intervals of two Mes.kapsula : inwards at meal times, on 1-2 caps. (depending on body mass index and severity of the disease), 3 times a Sutki.rastvor injection : in / m; Mix tentatively contents drug treatments (USD A) vial solvent (USD B) in one sprite and introduce to 3 ml three times a week for 4-6 Ned.effeguo injections combined with the admission of the drug inside.

Storage conditions

por.d / r-ra reception inside : At room temperaturer-r d / in.v / m : At room temperature

Shelf life

por.d / r-ra reception inside : 3 gu.r-r d / in.v / m : 2 grams.

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