Etalfa

Roman name

Etalpha #

The composition and the form of

1 capsule contains alfakalzidola 0.25, or 1 µ g; in a contour acheikova packing 10 pcs. , in a cardboard unit 3 and d0a0 1 package sootvetstvenno.1 ml drops for oral admission-2 µ g, in a dark bottle glass to 20 ml, in a cardboard package flakon.1 1 ml solution for injection-2 µ g; 182,000,000 in the 0.5 or 1 ml, in a contour acheikova packing 10 pcs.

Of drugs

D-vitaminopodobnoe governing calzi-fosfornyi exchange. COMPENSATION deficiency of endogenous products 1,25-дигидроксивитамин�� D_3 in the kidneys. Intussusception increases absorption of calcium and phosphorus, and their reabsorbqiyu in the kidneys and stimulates the bone mineralization, reduces the paratireoidnyi hormone in the blood.

Pharmacokinetics

Bioavailability when administered at about 100%. After the intake is fast becoming a liver to the active metabolite, 1,25-digidroksivitamin D_3, C_max which is a 12 hour, and T_1/2 is about 35 hours

Indications

Violations fosforno-calzievogo exchange : renal osteodistrofia, gipoparatireoz (posleoperazionny, idiopathic), psevdogipoparatireoz, giperparatireoz the defeat bones, rickets (vitamin D-rezistennetary, vitamin D-zawisimy associated with malabsorbziei and malnutrition, newborn), osteomalacia, gipocalziemia in newborns malabsorbece calcium osteoporosis.

Pregnancy and lactation

Perhaps only if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, gipercalziemia, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : rarely weakness, fatigue, dizziness, Sonlivosti.so part of the intestine : dry mouth, nausea, feeling discomfort epigastrii, constipation; Rarely increased ALT and AST in the Plazme.so metabolism : rarely gipercalziemia; Very rarely Improvement LPVP plasma, giperfosfatemia (in patients with pronounced impaired kidney). Other : rarely tachycardia, skin rashes, itching of the skin.

Specific guidance

You can combine with estrogenami and antirezorbtivei means. In renal osteodystrophies possible joint appointment means connecting phosphate (to prevent giperfosfatemii).

Patient interaction

Kolestiramin, sukralfat, antatsida, albumin products, mineral oils reduce inflammatory; Barbiturates, anti-convulsants increase metabolism. Together with the use of drugs naperstanki increased risk of heart rhythm, with antatidami - gipermagniemii with drugs calcium tiazidnami dioretikami, vitamin D and its derivatives-gipercalziemii.

Overdosing

Symptoms : weakness, weakness, dizziness, headache, palpitation, dry mouth, indigestion, pain in epigastria and abdomen, nausea, vomiting, constipation or diarrhoea, pain in the bones, Zud.lechenie : washing stomach, a mineral oils, in the most severe cases, the establishment of izotoniceski solution of sodium chloride (in / in), loop dioretikov, glucocorticoids.

Precautions

Treatment starts with the minimum doses under the supervision of the calcium and phosphorus plasma (once a week). Be wary designate patients who are vulnerable to the gipercalziemii, especially when there urolithiasis.

Dosing and Administration

Inside, in / on, every day. The duration of the physician individually depending on the nature of the disease and the effectiveness of therapy. Adults : when rahite osteomalation and in the dose of 1-3 g / day in gipoparatireoze, 2-4 µ g / day, with osteodystrophies to 2 µ g / day, with postmenopauzne, senilnom, steroidnom and other osteoporosis-0.5-1 g / sut. Children weighing less than 20 kg, 0.01 g / kg / day, 20 kg and above 1 µ g / day (except in the case of renal osteodystrophies when intake is 0,04-0,08 g / kg / day).

Storage conditions

Drops for reception inside : When temperature 8-15 ° Ckaps. : At room temperature no higher than 25 ° Cr-r d / in. : When temperature is not above 15 ° C

Shelf life

Drops for admission into : 3 g.kaps. : 3 gu.r-r d / in. : 2 grams.

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