Dimephosphon

Chemical name

Dimethyl ether 1,1-диметил-3-оксобутил��осфоновой acid

Gross

C8-H17-P-O4

Characteristics

Aziklicescoe organophosphorous соединение.Бесцветна�� or yellowish transparent liquid with a smell and bitter taste, pH 2.0-4.0. Rastvorima easy in the water.

Of drugs

Drugs, the cell, antiinflammatory, immunomodulirutee, antihypoxia, radioproteguoe. Is antioxidant properties dozozawisimo reduces the intensity of peroxide oxidation of lipids, spontaneous spirit and Adf-inducyrovannuu agregatia increases protivookislitionay of platelets and reduces the quantity of product peroxide oxidation of lipids. Normalizes kislotno-osnownoe state at the expense of the metabolic activation of the gene (especially kidney, and lung), vnutriorgannogo increase blood flow and metabolism woven. And next нейрофармакологическ их effects : neuroprotective, antidepressive, and the anti-protivojishemicakim, stressprotective, mnemotroponam and antiamnesticski. Improves cerebral blood circulation, ordinary tone cerebral vessels and blood brain, improves venous outflow. Egusing activity and zerebroprotectivee properties attributable to the protection neirometabolicescoy brain-carbohydrate targets and the energy exchange, prevents activation peroxide oxidation of lipids, increases active antioxidant enzymes in the brain tissue. The local application has antiseptic effect, enhances the protective functions of the skin and mucous membranes Obolocek.posle single administered orally absorbed adequately. C_max through a 120-180 min. Easily passes gistogematicalkie barriers and relate to the various organs and tissues. The largest concentrations are in the spleen, brain and Eritrocitah.pri traumatic damage to the brain has a beneficial effect on the metabolism and electrical activity; ® vazomotornuu zefalgiu; Reduces oxygen demand cloth brain, heart and respiratory insufficiency central genesis, to reverse focal Hemispheric and stem symptoms. Eliminates allergic inflammation, in particular in developing lakotrienzawisimoy reaction rejecting sulfitov decline of bronchial asthma and atopic dermatitis. Along with vitamins, enzymes pankreaticakimi and holestiraminom in children with inherited энтеро-оксалурически�� syndrome slows progression of the disease and increase life expectancy.

Indications

Violations of cerebral circulation (primary manifestations, temporary heart attacks and ischemic hemorrhagic stroke, the effects of previous existing stroke, discirkulatornaya encephalopathy, and mielopatia radikulopatia) from atherosclerosis, hypertension, a disease vazomotorna dystonia, spine diseases, neirohirurgical operating trauma the brain and spinal cord, skull trauma (Hudeh and bruised brain), depression and Ménière disease, autonomic dysfunction, acute and chronic diseases of the respiratory system with subcompencirovanna pulmonary hypertension bronhospasticski of bronchial obstruction (chronic bronchitis, bronchial asthma, lung tuberculosis), acidosis with pneumonia, chronic nonspecific lung diseases, acute respiratory viral infections, diabetes and aftercare period atopica bronchial asthma and pollinozy children, atopic dermatitis, �нфекционно-воспалите льные diseases of the skin and mucous membranes (acne, birthmarks, �нойно-воспалительные �slojnenia in exit spokes apparatus suicide), Lor-organov disease and dental, mukozita with radiation therapy of malignant neoplasms, infected wounds, trophic ulcers, rahitopodobne disease in children hereditary et нтеро-оксалурический �indrom.

Contraindications

Hypersensitivity expressed by the human kidney, convulsions increased preparedness.

Side-Effects

Diarrhoeal phenomenon (with ingestion), fall (early treatment).

Patient interaction

Do antiagregatine of aspirin.

Precautions

And bitter taste, so to facilitate the admission of students should zapiwati milk, fruit juice or sweet tea. When at the beginning of treatment to keep refrain from driving vehicles and occupation, requiring high speed and reaction.

Dosing and Administration

Inside, naruzhno in / 386/1989 Inside, squeezed water in the form of the solution for adults and children 30-50 mg / kg (or at the rate of 1 ml of 15% solution of 5 kg body weight), 1-4 times a day; Course duration : in case of cerebral circulation and Ménière syndrome, autonomic dysfunction, diseases of the respiratory system and azidoze, atopicescoy bronchial asthma in children - 1-4 weeks, head trauma, ranging from 3 weeks to 2 months. When planning neurosurgical operations for a period of five days before and 14 days after the operation to prevent the deterioration pollinoza during the three weeks before the expected seasonal decline, and during the period of plant dust. External : when инфекционно-воспалит��льно-аллергических Diseases skin and mucous membranes, in the form of casts, and turund primocek with daily solution to the disappearance of clinical manifestations; for the prevention of radiation mukozita-washing towels, wetted solution are on the projection beams of radiation for 20 minutes before exposure Dozy.v / in : struino The content of 1-2 vials throw 10-20 ml of sterile water for injection or 0.9% solution of sodium chloride, drip, in the 200-400 ml of 0.9% solution of sodium chloride. Misleading 1-4 times a day for 7-10 days.

Literature

Pogomi NN, Pampura A., I. Chernov etc. The sulfite compounds within bronchial asthma and atopic dermatitis in children / / Ros. vestn. Perinatology and Pediatrics .- 1998 .- T. 43 N-6 .- C. 15-19.

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