Gelofuzin

Roman name

Gelofusine #

The composition and the form of

1 polymer container with 500 ml for infusions of sukqingirovannogo (modified liquid) gelatin 20 g, sodium chloride 3.5 g, sodium hydroxide 680 mg (including ion sodium 154 mmol chlorine ions 120 mmol); in a box 10 pcs.

Of drugs

Plazmozameshchatee, improves microcirculation. Increases BCC.

Pharmacokinetics

Has mnogofaznuu curve off with T_1/2 about 9 a.m. 75% shall be provided with urine, 15% from faeces. The remainder is proteolizu. Cumulation is not observed, even with renal failure.

Farmakodinamika

The increase in circulating blood leading to an increase in venous return and cardiac release, the normalization of AD and white peripheral tissues. Calling osmoticeski diurez, maintain renal function in shock. Is lowering blood viscosity, improves. Through its коллоидно-осмотическ��м properties, prevents or reduces the likelihood of interstitial oedema. Objemozameshchati effect is 100% after the introduction of the drug is about 5 hours

Indications

Absolute and relative gipovolemia (prevention and treatment); State accompanied by sgutmenem blood (to gemodilucia); IVF blood, preventing arterial hypotension with or spinal anesthesia epiduralna; As a solvent in giving insulin preparations (with a view to reducing its losses due to adsorption on the walls of infusion tanks and tubes).

Pregnancy and lactation

The effects embriotoksicskih Gelofuzina missing, but since the possibility of allergic reactions can not be ruled out completely, he can be appointed during pregnancy only in situations where the potential benefit to the mother than the potential risk to the fetus. No data on the penetration of Gelofuzina in mother's milk.

Contraindications

Gipervolemia had a history anaphylactoidnykh reactions to gelatin.

Side-Effects

There anaphylacticskie response (0,008-0,02% of the cases). Gelofuzin not affected by the liquidation of the blood, but with a massive drug infusions may violate down due to the effect of breeding.

Specific guidance

You can change the diagnostic tests for glucose, fructose, cholesterol, fatty Kislota.nelia use mutnye solutions.

Patient interaction

You can impose solutions electrolytes, carbohydrates, blood products. The confused with VIP emulsiami. Desirable, though not impossible, to the addition of solution Gelofuzina drugs affecting Stroke tone, barbiturates, miorelaksantov, antibiotics, glucocorticoids.

Overdosing

Symptoms : Gemodilucia.lechenie : symptomatic (after infusions).

Precautions

It should not be reduced gematokrita less than 25% (in the elderly-30%). In chronic heart failure infuziu need to be slow because of the possible development zirkulatorna Peregeorgki.gelofuzin should be used with caution in gipergidratace, kidney failure, bleeding diatezah, oteke light, the lack of sodium and Kalia.pri more Infusion 2-3 l should monitor the concentration of protein in the serum, especially when there is inflammation of tissue (and, if necessary, drugs to human albumin).

Dosing and Administration

B / 386/1989 The mode set individually, the lack of plasma dynamics HR, AD diureza, the white peripheral tissues. In krovopotere heavy, as well as with the objective of the predoperatinom period, or during the operation, introducing 500 ml for 1-3 h, in order to maintain the BCC shocked to 15 litres in 24 hours

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