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Allopurinol

See also Allopurinol

Roman name

Allopurinol

The composition and the form of

1 tablet contains allopourinola 100 mg; in vial 50 pc.

Of drugs

Противоподагрическое . Ingibiruet xantinoxydazu that turns gipoksantin in xantin, xantin in stays acid; Reduces the concentration of uric acid and its salts in liquid environments organism and urine, prevents uratnah sediments.

Indications

Gouty arthritis, stone, skin tofusa (to reduce the synthesis uratov and uric acid with their deposits in the tissues), the prevention of acute urolithic nefropatii (including in the treatment of protivoopujolevami drugs).

Contraindications

Renal failure in violation excretory functions pregnancy.

Side-Effects

Negotiable angioimmunoblastnaya limfadenopatia granulematosny and hepatitis, anaemia, agranulozitos, aplastic anaemia (more commonly in patients with compromised function of the liver and kidney), nausea, vomiting, fever, malaise, fatigue, headache, disturbances of view, cataracts, a violation of taste, disease, vertigo, ataxy, drowsiness, coma, depression, paralysis parestesia, neiropatia changes generic patches staining hair, alopecia, stenocardia, aetiology, hypertension, oedema, furunkoulez, giperglikemia, giperlipidemia, gematuria, uremia, ginekomastia, infertility, impotence, allergic reactions (skin), swelling angioneuroticeski.

Patient interaction

Do effect azatioprina, 6-mercaptopourina, hlorpropamida (slowing down), especially in patients with renal insufficiency, modifies - theofillina, vidarabina, Amoxicillin, furniture, cyclosporine. Urikozuricescie drugs (probenecid), salicilata reduce allopourinola activity.

Precautions

Do not start treatment until edema acute gout attack; In the first month of treatment recommended prophylactic administration NPVS or kolhitina; In the case of acute gout attack in the face of treatment must be to appoint more противовоспалительны е funds. In a serious breach of the kidney or liver dose should be reduced. When coupled with the application or azatioprinom 6-mercaptopourinom last dose reduced fourfold. Be wary combine with vidarabinom. Patients receiving theofillin, it is necessary to control its concentration in the blood. Not recommended for use in combination with amoksicillinom, ampicillinom, ziklosporinom. Use during pregnancy and lactation can be only in the absence of any alternative treatment.

Dosing and Administration

Inside, the food. Starting with 100 mg / day, one, and then increase the dose gradually. If the dose of 300 mg / day are side effects from the blood, can float reception. Adults, 100-200 mg / day, with a moderate, 300-600 mg / day, with heavy-700-900 mg / Sut.detam to 15 years, 10 to 20 mg / kg / day (up to 400 mg / day maximum). When expressed kidney failure is 100 mg / day or 100 mg at intervals more than one Deny.pojilam patients recommended the lowest dose.

Storage conditions

table. : List B. In dry place so that the temperature does not exceed 35 ° C

Shelf life

table. : 5 years

Indications for use

For the treatment and prevention of diseases involving gieperriquemiei (high uric acid in the blood) and the formation of stones uratnah (consisting of salts uric acid) : primary and secondary gout, a disease anesthetic education concrements (stones) containing urata, primary and secondary giperuriquemia.

Form of

Pill 0.1 grams per pack of 50 pieces.

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