Allopourinol-egis

Roman name

Allopurinol-Egis

The composition and the form of

1 tablet contains allopourinola 100 or 300 mg; Patients in the dark glass of 50 or 30 pc. respectively, in paper cartons 1 a bottle.

Of drugs

Protivopodagricescoe, gipouriquemicescoe. Ingibiruet xantinoxydazu lowering uratov education in the serum, prevents deposition of tissues and the kidneys.

Pharmacokinetics

Almost all (90%) absorbed from the digestive tract. The liver influenced xantinoxydasy becoming alloksantin, which also prevent the formation of uric acid. After one reception allopourinola C_max plasma is a 1.5 hour alloksantina through 4.5 hours T_1/2 allopourinola is 1-2 hour alloksantina-about 15 hours About 20% of dose extracted through intestine, and the rest of the allopourinola and its metabolites-kidney.

Indications

Gout, giperuriquemia (with the true policitemii, mieloidna metaplazii, haematological diseases zitostaticescoy and radiation therapy), mochekisly nefrourolitiaz (prevention).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity expressed human liver and kidneys (azotemia), idiopathic hemochromatosis (including family history), giperuriquemia asymptomatic, acute gout attack, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : rapid, sleep disturbance, depression, amnesia, cataracts, conjunctivitis, Ambliopia.so the circulatory system and blood (blood, gemostaz) : rarely vasculit, pericardit, aetiology, throm, thrombocytopenia, eozinofilia, lakopenia, leucocytosis, aplastic and haemolytic anaemia, retikulozitos, Limfozitoz.so part of the intestine : nausea, vomiting, stomachache, diarrhea, rarely granulematosny hepatitis, the increase in the liver and transaminaz alkaline Fosfataza.so the urogenital system : rarely instersticialny jade, gematuria, proteinurija and peripheral Oteki.allergicakie reactions : exantema fever, rarely bronhospazm.

Patient interaction

Do methotrexate toxicity and azatioprina (slowing their biotransformatia) antikoagulyannetary kumarinov effect, the impact of drugs on bone marrow.

Dosing and Administration

Inside, after eating, squeezed of water. Adults on 300 mg once a day, if necessary dose can be increased to 100 mg every 1-3 weeks (under the supervision of the content of uric acid in the serum). Maintaining daily dose-600 mg, the maximum 800 mg, 2-4 in the reception. For two days before the start of anticancer therapy appointed a daily dose of 800 mg for a period of two to three days. For children between 10 and 20 mg / kg / sut. During the treatment, there is a need for a diurez at least two litres a day.

Storage conditions

table. : List B. In temperaturetabl room. : List B. The temperature of 15-25 ° C

Shelf life

table. : 5 years

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