Allupol

Roman name

Allupol #

The composition and the form of

1 tablet contains allopourinola 100 mg; blistere in 25 pcs. , in a cardboard box two blisters.

Of drugs

Gipouriquemicescoe, противоподагрическое . Ingibiruet xantinoxydazu inhibits oxidation gipoksantina in xantin and further education uric acid; Reduces uratov, with the low levels in the serum, preventing formation of tissues and the kidneys increases down with urine and gipoksantina xantina.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract. Oxidized to oksipourinola (continuing ability xantinoxydazu inhibition). T_1/2 - 18-30 h.

Indications

Gout, giperuriquemia (with zitostaticescoy and radiation therapy, treatment mercaptopourinom, azatioprinom, tiazidami).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Pregnancy, breast feeding, child age (except secondary gieperriquemii with tumours).

Side-Effects

The worsening gout (in the initial period of treatment); Diarrhoeal disorders (feeling overflows in epigastria, nausea, vomiting, diarrhea); Rarely, dizziness, headache, weakness, drowsiness, and pain in muscles, changes in the cells of peripheral blood (lakopenia, thrombocytopenia), haemolytic anaemia (when there is a shortage of glukozo-6-fosfatdegidrogenaza), allergic reaction (rash, itching of the skin).

Specific guidance

During treatment patients showed plenty of drink for diureza allowance in the amount of not less than 2 litres.

Patient interaction

Do effect mercaptopourina and azatioprina, gematotoksicnosti ziklofosfamida, gipoglikemia caused hlorpropamidom. Benzodaron, benziobromaron and probenecid reduces allopourinola activity. Ampicillin contributes to the development of skin reactions.

Precautions

To prevent worsening gout to the simultaneous appointment kolhitina, indometacin or fenilbutazon.

Dosing and Administration

Inside, after eating, to 200-400 mg once a day, if necessary, up to 600 mg in a few receptions. Against the backdrop of anticancer therapy, 800 mg (not more). Children under the age of 6 -- 50 mg three times daily, 6-10 years, 100 mg three times a day.

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