Benzbromarone

Chemical name

(3,5-Дибром-4-гидроксифе нил)(2-этил-3-бензофура��ил)метанон

Gross

C17-H12-Br2-O3

Characteristics

Mikronizirovanny powder.

Of drugs

The drugs-gipouriquemicescoe, urikozuricescoe. Ingibiruet reabsorbqiyu uric acid in the proximal bone, and increases its withdrawal kidneys and the intestine. Oppressing Purinov.bystro synthesis and is absorbed in the digestive tract. Biotransformiroetsa in the liver before and benzarona bromobenzarona with pharmacological activity. Write mainly faeces and, in smaller quantities, with urine.

Indications

Gout, giperuriquemia, incl. tiazid-inducyrovannaya, hematologic diseases, psoriasis.

Contraindications

Hypersensitivity, the acute porphyria, heavy damage liver and kidneys, pregnancy, breast-feeding (at the end of treatment), children's age.

Side-Effects

Gastrointestinal disorders (diarrhea), increased joint pain (early treatment), acute gout attacks, the symptoms of renal deposition uratov, allergic skin reactions.

Patient interaction

Increases activity kumarinovykh anticoagulants. Effect salicilata weaken.

Precautions

During treatment should drink at least 1.5-2 litres alkaline liquid in the day to prevent sediment concrements in the Scottish waterways. Risk uratov deposition in acute gout attacks can be reduced appointment kolhitina or allopourinola. To use caution in patients with renal insufficiency. Do not start treatment at the time of acute gout attack.

Dosing and Administration

Inside, at the time of delivery, 50-100 mg (1 / 2 table). Once a day. In acute gout attacks designate short course on 1 / 2 table. three times a day for three days. The maximum dose for adults-2 table. (200 mg) a day.

Literature

R. Hill Benzbromarone : a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia / / Drugs - 1977 - V. 14 .- P. 349-366.

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